胃内幽门螺杆菌定植水平与代谢综合征的关系  

The relationship between the level of Helicobacter pylori colonization in stomach and metabolic syndrome

作　　者：王永平[1] 张丹[2] 周莹 白杨[4] 欧阳平[1] 阮伟清[1] 辛洪杰 WANG Yong-ping;ZHANG Dan;ZHOU Ying;BAI Yang;OUYANG Ping;RUAN wei-qing;XIN Hong-jie(Department of Physical Examination,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Department of Respiratory,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Department of Hepatobiliary surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院健康管理科,510515 [2]南方医科大学南方医院呼吸内科,510515 [3]南方医科大学南方医院肝胆外科,510515 [4]南方医科大学南方医院消化内科,510515

出　　处：《现代消化及介入诊疗》2020年第5期576-580,共5页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：广东省科技计划项目(2019A141405048);广东省科技计划项目(2017B02029003)。

摘　　要：目的分析胃内幽门螺杆菌(H.pylori)定植水平与代谢综合征(MS)的相关性。方法回顾分析2018年1月至2018年12月我院健康体检中心513名体检者资料,包括13C-尿素呼气试验检测结果,血生化指标,空腹血糖,血压及一般信息。根据13C-尿素呼气试验检测结果,以DOB值为衡量,将受试者分为正常组(H.pylori阴性组,DOB值<4)251例,轻度升高组(4≤DOB值<10)39例,中度升高组(10≤DOB值<25)130例,重度升高组(DOB值≥25)93例。比较不同H.pylori定植水平与MS的相关性。结果513名体检者中H.pylori感染率为50.9%,MS患病率为19.3%。与H.pylori阴性组相比较,H.pylori阳性组DOB值、舒张压、MS患病率存在显著差异(P<0.05)。胃内H.pylori定植水平(DOB值)与MS存在相关性(P=0.001)。同正常组相比,轻度升高组、中度升高组以及重度升高组的校正后OR值(95%CI)分别为0.61(0.07,4.85),1.39(0.52,3.74)和7.10(2.23,22.63)。结论体检人群中H.pylori感染与MS存在相关性,同时H.pylori胃内定植水平影响MS的患病风险。Objective To evaluate the colonization level of Helicobacter pylori(H.pylori)in stomach and its association with metabolic syndrome(MS).Methods Data of 513 individuals who took routine physical examination from January 2018 to December 2018 were enrolled in this study.The clinical information on the result of 13C-urea breath test(DOB value),biochemical variables,fasting blood glucose(FBG),blood pressure(SBP/DBP),body mass index(BMI)and the general information were collected and analyzed.According to the level of DOB value,the subjects were divided into H.pylori negative group(DOB value<4),mild elevation group(4≤DOB value<10),moderate elevation group(10≤DOB value<25),and severe elevation group(≥25).The association between the colonization level of H.pylori in stomach and MS was explored.Results H.pylori infection rate in 513 subjects taking routine physical examination was 50.9%and the prevalence of MS was 19.3%.Compared with H.pylori negative group,the DOB value,DBP,prevalence of MS were significantly increased in H.pylori positive group(P<0.05).DOB value level was significantly correlated with the occurrence of MS(P=0.001).Compared with that in normal DOB value group,the adjusted ORs in mild,moderate and severe elevation groups were 0.61(95%CI:0.07-4.85),1.39(95%CI:0.52-3.74)and 7.10(95%CI:2.23-22.63),respectively.Conclusion There was significant association between H.pylori infection and MS(P<0.05),also the patients with a DOB value level≥25 are exposed to a significantly increased risk for metabolic syndrome.

关 键 词：幽门螺杆菌 代谢综合征 体检人群 DOB值 

分 类 号：R573.3[医药卫生—消化系统] R589[医药卫生—内科学]