艾地苯醌治疗血管性痴呆临床效果观察  

Observation on clinical effect of idebenone in the treatment of vascular dementia

作　　者：吴小慧 吴柏棉 陈婉珉 刘石梅 郭灵 WU Xiao-hui;WU Bo-jin;CHEN Wan-min(Shunde District Wu Zhongpei Memorial Hospital,Foshan 528300,China)

机构地区：[1]广东省佛山市顺德区伍仲珮纪念医院,528300

出　　处：《中国实用医药》2020年第14期105-107,共3页China Practical Medicine

摘　　要：目的探讨艾地苯醌治疗血管性痴呆的临床效果。方法40例血管性痴呆患者作为研究对象,根据随机数字表法分为对照组和观察组,各20例。对照组给予奥拉西坦治疗,观察组给予艾地苯醌治疗。比较两组患者的治疗效果及治疗前后简易精神状态检查量表(MMSE)评分、日常生活能力评定量表(ADL)评分。结果治疗后,两组MMSE评分均高于本组治疗前,且观察组MMSE评分(19.24±0.45)分高于对照组的(18.82±0.49)分,差异有统计学意义(P<0.05)。治疗后,两组ADL评分均低于本组治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗优良率为80%,对照组治疗优良率为45%,观察组治疗优良率高于对照组,差异有统计学意义(P<0.05)。结论对血管性痴呆患者应用艾地苯醌治疗,可有效提高患者的认知功能和生活质量,增强临床疗效,具有临床推广意义。Objective To discuss the clinical effect of idebenone in the treatment of vascular dementia.Methods A total of 40 vascular dementia patients as study subjects were divided into control group and observation group by random number table method,with 20 cases in each group.The control group was treated by oxiracetam,and the observation group was treated by idebenone.The therapeutic effect,mini-mental state examination(MMSE)score and activities of daily living before and after treatment were compared between the two groups.Results After treatment,MMSE score of the two groups were higher than those before treatment of the same group,and MMSE score(19.24±0.45)points of the observation group was higher than that of the control group(18.82±0.49)points,and the difference was statistically significant(P<0.05).After treatment,ADL score of the two groups were lower than those before treatment of the same group,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).The excellent rate of treatment of the observation group was 80%,which was 45%of the control group.The excellent rate of treatment of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Idebenone shows remarkable clinical efficacy for the treatment of patients with vascular dementia,which can improve the cognitive function and quality of life of patients.It has asignificance to be popularized in clinic.

关 键 词：血管性痴呆 艾地苯醌 奥拉西坦 

分 类 号：R749.13[医药卫生—神经病学与精神病学]