LA16c⁃313D11.11与miR⁃205⁃5p在子宫内膜癌中的表达及意义  

Expression and Significance of LncRNA⁃LA16c⁃313D11.11 and miR⁃205⁃5p in Endometrial Carcinoma

作　　者：韩雪松[1] 丁雪 赵鹏[3] 于辉[4] 辛卫娟 HAN Xuesong;DING Xue;ZHAO Peng;YU Hui;XIN Weijuan(Obstetrics,the first affiliated hospital of kunming medical university,Kunming,Yunnan,China,650032;Department of obstetrics and gynecology,fudan university,Shanghai,China,200090;Department of cardiology,dezhou people's hospital,Dezhou,Shangdong,China,253001;School of medicine and nursing,dezhou university,Dezhou,Shangdong,China,253001)

机构地区：[1]昆明医科大学第一附属医院妇产科,云南昆明650032 [2]复旦大学附属妇产科医院妇科,上海200090 [3]德州市人民医院心内科,山东德州253001 [4]德州学院医药及护理学院,山东德州253001

出　　处：《分子诊断与治疗杂志》2020年第5期579-582,591,共5页Journal of Molecular Diagnostics and Therapy

基　　金：上海市自然基金(16ZR1404100)。

摘　　要：目的检测LA16c⁃313D11.11及miR⁃205⁃5p在正常子宫内膜、子宫内膜非典型增生(EAH)和子宫内膜癌(EC)组织中的表达情况及意义。方法采用实时荧光定量PCR(qRT⁃PCR)技术分析LA16c⁃313D11.11及miR⁃205⁃5p在60例子宫内膜癌组织,20例子宫内膜非典型增生组织和20例正常子宫内膜组织中的表达。结果LA16c⁃313D11.11在子宫内膜癌中表达明显降低,而miR⁃205⁃5p在子宫内膜癌中表达明显升高。LA16c⁃313D11.11和miR⁃205⁃5p的表达与子宫内膜癌FIGO分期及淋巴结转移明显相关(P<0.05)。LA16c⁃313D11.11与miR⁃205⁃5p在子宫内膜癌中呈负性相关(P<0.05)。结论子宫内膜癌中LA16c⁃313D11.11可能通过内源竞争抑制miR⁃205⁃5p的表达来发挥作用,也许是诊断和治疗子宫内膜癌及判定其预后的一个新的标志物。Objective To analyze the expression and significance of LA16c⁃313D11.11 and miR⁃205⁃5p in normal endometrium,endometrial atypical hyperplasia(EAH)and endometrial carcinoma(EC)tissues,and to explore its clinical application.Methods Quantitative real⁃time PCR(qRT⁃PCR)was performed to analyze expressions of LA16c⁃313D11.11 and miR⁃205⁃5p in 60 EC tissues,20 atypical EAH tissues and 20 normal endometrium tissues.Results The expression of LA16c⁃313D11.11 was significantly reduced in endometrial cancer,while the expression of miR⁃205⁃5p was significantly increased in endometrial cancer.The expressions of LA16c⁃313D11.11 and miR⁃205⁃5p were significantly correlated with FIGO stage of endometrial cancer and lymph node metastasis(P<0.05).LA16c⁃313D11.11 and miR⁃205⁃5p were negatively correlated in endometrial cancer(P<0.05).Conclusion In endometrial cancer,LA16c⁃313D11.11 may play a role by inhibiting the expression of miR⁃205⁃5p through endogenous competition.LA16c⁃313d11.11 could be a new marker for the diagnosis and treatment of endometrial cancer and its prognosis.

关 键 词：子宫内膜癌 LA16c⁃313D11.11 miR⁃205⁃5p 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]