血清EGFL7、MTA1表达与鼻咽癌患者临床特征及预后的关系  

Correlation of serum EGFL7 and MTA1 with clinical characteristics and prognosis of patients with nasopharyngeal carcinoma

作　　者：冯睡 尹金淑[1] 谢洪[1] 姬巍[1] 刘艾竹[1] 彭洪[1] FENG Shui;YIN Jinshu;XIE Hong;JI Wei;LIU Aizhu;PENG Hong(Department of Otorhinolaryngology Head and Neck Surgery,Beijing Shijitan Hospital,Capital Medical Uni⁃versity,Beijing,China,100038)

机构地区：[1]首都医科大学附属北京世纪坛医院耳鼻咽喉头颈外科,北京100038

出　　处：《分子诊断与治疗杂志》2020年第5期616-620,共5页Journal of Molecular Diagnostics and Therapy

基　　金：北京市科学技术委员会自然类基金项目(Z161100000516006)。

摘　　要：目的探究鼻咽癌患者血清表皮生长因子样结构域7(EGFL7)、肿瘤转移性相关基因1(MTA1)蛋白表达及与临床特征及预后的相关性。方法选取本院2014年1月至2016年1月收治的鼻咽癌患者病毒组织60例,其中转移患者22例作为转移组,未转移患者38例作为未转移组,以同期20例正常鼻咽部组织作为对照组,对比3组血清EGFL7、MTA1蛋白水平、微血管密度(MVD)、淋巴管密度(LVD)水平,比较不同临床特征患者EGFL7、MTA1水平,Spearman相关性分析血清EGFL7、MTA1蛋白与MVD、LVD相关性,Kaplan⁃meier生存函数分析EGFL7、MTA1与患者预后的关系。结果3组血清EGFL7、MTA1蛋白及MVD、LVD水平比较结果:鼻咽癌患者转移组>鼻咽癌患者未转移组>对照组,差异具有统计学意义(P<0.05)。不同性别、年龄、EB病毒相关抗体阴阳性血清EGFL7、MTA1蛋白水平比较,差异无统计学意义(P>0.05);不同TNM肿瘤分期、有无淋巴结转移、浸润深度、分化程度患者血清EGFL7、MTA1蛋白水平比较差异具有统计学意义(P<0.05)。相关性分析结果显示,EGFL7及MTA蛋白分别与MVD、LVD存在显著正相关性(P<0.05)。以鼻咽癌患者血清EGFL7、MTA1平均值为中位数,分为低EGFL7组、高EGFL7组及低MTA1组、高MTA1组,Ka⁃plan⁃meier生存函数结果显示,低EGFL7组的MST高于高EGFL7组的MST,差异具有统计学意义(P<0.05)。低MTA1组MST高于高MTA1组的MST,差异有统计学意义(P<0.05)。结论血清EGFL7、MTA1表达水平与鼻咽癌患者临床分期及淋巴结转移存在密切关系,血清EGFL7、MTA1高表达鼻咽癌患者预后较差。Objective To investigate the expression of epidermal growth factor⁃like domain 7(EGFL7)and tumor metastasis⁃associated gene 1(MTA1)protein in patients with nasopharyngeal carcinoma and to evaluate the correlation with clinical characteristics and prognosis.Methods 60 cases of nasopharyn⁃geal carcinoma patients admitted in our hospital from January 2014 to January 2016 were selected,including 22 metastatic patients as the metastatic group,38 non⁃metastatic patients as the non⁃metastatic group.20 nor⁃mal healthy controls were slected as the control group.The serum levels of EGFL7 and MTA1,microvessel density(MVD)and lymphatic vessel density(LVD)levels were measured and compared among the three groups.Spearman correlation analysis was used to analyze the correlation between serum EGFL7,MTA1 and MVD,LVD.Kaplan⁃meier survival function was used to analyze the relationship between EGFL7,MTA1 and patient prognosis.Results Comparison of the serum levels of EGFL7 and MTA1 and MVD or LVD levels in the three groups:Metastatic group of patients with nasopharyngeal cancer>non⁃metastatic group of patients with nasopharyngeal cancer>Control group,the difference was statistically significant(P<0.05).There was no significant difference in the levels of EGFL7 and MTA1 protein in different genders,ages,and EB virus⁃re⁃lated antibody negative positive serum(P>0.05).t There were statistically significant differences in serum EGFL7 and MTA1 protein levels among patients with different TNM tumor stages,presence or absence of lymph node metastasis,depth of invasion,and degree of differentiation(P<0.05).Correlation analysis showed that EGFL7 and MTA had a significant positive correlation with MVD and LVD,respectively(P<0.05).Based on the median values of serum EGFL7 and MTA1 in patients with nasopharyngeal carcinoma,they were divided into low EGFL7 group,high EGFL7 group,low MTA1 group,and high MTA1 group.Ka⁃plan⁃meier survival function results showed that the MST with the low EGFL7 group was higher than that of th

关 键 词：鼻咽癌 表皮生长因子样结构域7 肿瘤转移性相关基因1 临床特征 预后 

分 类 号：R739.63[医药卫生—肿瘤]