环状RNA在急性髓系白血病中的研究进展  

Advances of circular RNAs in acute myeloid leukemia

作　　者：张蕾[1] 查显丰[1] 温旺荣[1] ZHANG Lei;ZHA Xianfeng;WEN Wangrong(Center of Clinical Laboratorial Medicine,The First Affiliated Hospital of Jinan University,Guangzhou,Guangdong,China,510630)

机构地区：[1]暨南大学附属第一医院临床检验中心,广东广州510630

出　　处：《分子诊断与治疗杂志》2020年第2期123-126,165,F0002,共6页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金青年项目(81400109)。

摘　　要：环状RNA是一种内源性非编码RNA(ncRNAs),近年来随着高通量测序和转录组谱分析技术的发展使得人们能够鉴定出与许多生物过程以及疾病的发生和发展有关的环状RNA(circRNAs)。其结构稳定、序列保守、功能多样、具有组织细胞特异性。环状RNA已被证明不仅与胃癌、结肠癌、乳腺癌等实体肿瘤的发生与发展、转移、预后等显著相关,在血液系统肿瘤尤其是白血病发挥重要作用。目前研究发现,白血病中circRNAs可以作为诊断的新生物标记,并为白血病提供有希望的治疗方法和新颖的药物筛选策略。对白血病中circRNAs的全面了解是开展临床应用研究的前提。CircRNAs are endogenous non⁃coding RNAs(ncRNAs).Over the past decades,the development of high⁃throughput sequencing and transcriptome spectrum analysis have people to identify circular RNAs(circRNAs)involved in many biological processes,including the occurrence and development of diseases.They have stable structures,conserved sequences,diverse functions,and tissue cell specificity.CircRNAs have been shown to be significantly correlated with the occurrence,development,metastasis and prognosis of not only solid tumors such as gastric cancer,colon cancer and breast cancer,but also tumors of the circulatory system,especially leukemia.Current studies have found that circRNAs in leukemia can be used as new biomarkers for diagnosis,and lead to promising treatment methods and novel drug screening strategies for leukemia.A comprehensive understanding of circRNAs in leukemia is a prerequisite for the development of clinical application.

关 键 词：环状RNA 急性髓系白血病 肿瘤标志物 治疗靶标 

分 类 号：R733.71[医药卫生—肿瘤]