ATM蛋白激酶促细胞增殖作用研究进展  

Advance of ataxia⁃telangiectasia mutated protein kinase promoting cell proliferation

作　　者：唐石伏[1] 吴婉君 阳建伶 马兴璇 杨建青 TANG Shifu;WU Wanjun;YANG Jianling;MA Xingxuan;YANG Jianqing(Department of Lab Medicine,the Third Affiliated Hospital,Guangxi University of Chinese Medicine,Liuzhou,Guangxi,China,545001;Department of First Surgery,the Third Affiliated Hospital,Guangxi University of Chinese Medicine,Liuzhou,Guangxi,China,545001)

机构地区：[1]广西中医药大学第三附属医院检验科,广西柳州545001 [2]广西中医药大学第三附属医院外一科,广西柳州545001

出　　处：《分子诊断与治疗杂志》2020年第2期249-252,258,共5页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金地区科学基金项目(81560430);广西自然科学基金项目(2016JJA140484)。

摘　　要：一直以来,共济失调毛细血管扩张突变基因(ATM)编码的蛋白激酶相关研究主要集中在DNA双链断裂损伤修复领域。近年来越来越多研究表明,氧化激活的ATM激酶具有重要的促细胞增殖作用,其潜在的机制与其氧化还原稳态维持功能、糖代谢调控功能和细胞增殖信号通路活性调节功能等密切相关。本文综述ATM激酶相关研究进展,尤其是其增殖调控功能相关研究,将有利于深入了解ATM蛋白激酶促细胞增殖的机制及其临床应用。The research on Ataxia telangiectasia mutated(ATM)kinase has been focusing on the field of DNA double⁃strand break repair.In recent years,many studies have shown that oxidation⁃activated ATM kinase has an important role in promoting cell proliferation,and its underlying mechanism is closely related to its redox homeostasis maintenance,glucose metabolism regulation and cell proliferation signaling pathway activity.This article reviews the progress of ATM kinase⁃related researches,especially related to its proliferation regulation,which will be helpful for a deeper understanding of the mechanism of ATM protein kinase to promote cell proliferation and clinical application.

关 键 词：ATM基因 ATM蛋白激酶 细胞增殖调控 

分 类 号：R341[医药卫生—基础医学]