EpCAM和β-catenin在唾液腺黏液表皮样癌中的表达及意义  

Expression and Significance of EpCAM andβ-catenin in Mucoepidermoid Carcinoma of Salivary Glands

作　　者：朱云娜 郑绘霞[1] 肖虹[1] 万惠丽 吕佳乐 梁钢[1] 李宁[1] ZHU Yunna;ZHENG Huixia;XIAO Hong;WAN Huili;LV Jiale;LIANG Gang;LI Ning(Department of Pathology,The First Hospital of Shanxi Medical University,Taiyuan 030001,China;First Clinical College,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院病理科,山西太原030001 [2]山西医科大学第一临床学院,山西太原030001

出　　处：《口腔医学研究》2020年第5期433-436,共4页Journal of Oral Science Research

摘　　要：目的:探讨唾液腺黏液表皮样癌(mucoepidermoid carcinoma,MEC)中EpCAM和β-catenin蛋白表达与临床病理意义。方法:免疫组化Envision法检测57例MEC和20例正常唾液腺组织中EpCAM和β-catenin的表达。结果:(1)EpCAM、β-catenin的阳性率在MEC明显高于正常组织(P=0.002,P=0.001);EpCAM在高、中、低分化MEC中阳性率分别为36.36%、61.11%、82.35%,差异有统计学意义(P=0.015),β-catenin的阳性率分别为45.45%、72.22%、88.24%,差异有统计学意义(P=0.016);(2)EpCAM表达与淋巴结转移情况相关(P=0.024),EpCAM和β-catenin表达均与患者年龄相关(P=0.004,P=0.004),与患者性别、肿物发生的部位等均无关;(3)EpCAM和β-catenin在MEC中的表达呈正相关(R=0.48,P<0.001)。结论:EpCAM和β-catenin表达与MEC恶性程度相关,联合检测二者有助于MEC的分级、辅助预测预后,并为MEC的靶向治疗提供依据。Objective:To investigate the expression and clinicopathologic significance of EpCAM andβ-catenin in mucoepidermoid carcinoma(MEC).Methods:The expressions of EpCAM andβ-catenin in 57 cases of MEC and 20 cases of normal salivary gland tissues were detected by immunohistochemical staining(Envision method).Results:The positive expression rate of EpCAM andβ-catenin in MEC was significantly higher than that in normal tissues(P=0.002,P=0.001).The positive expression rates of EpCAM in MEC with high,medium,and low differentiation were 36.36%,61.11%,and 82.35%,respectively(P=0.015),and the positive expression rates ofβ-catenin were 45.45%,72.22%,and 88.24%,respectively,with statistically significant differences(P=0.016).Both EpCAM andβ-catenin expression were correlated with patient age(P=0.004,P=0.004).EpCAM was correlated with lymph node metastasis(P=0.024),and the expression of EpCAM andβ-catenin was unrelated to the gender of patients and the location of tumor.The expression of EpCAM andβ-catenin in MEC was positively correlated(R=0.48,P<0.001).Conclusion:Expressions of EpCAM andβ-catenin were associated with MEC malignancies.Joint tests could help to evaluate MEC,assist in predicting prognosis,and provide basis for the targeted treatment of MEC.

关 键 词：黏液表皮样癌 EPCAM Β-CATENIN 

分 类 号：R73[医药卫生—肿瘤]