女性重性抑郁障碍患者体质量指数与脑白质完整性异常的相关性研究  

Correlation between body mass index and abnormal white matter integrity in female patients with major depressive disorder

作　　者：李汇子 汤艳清[2] 王菲[2] 孔令韬[2] LI Hui-zi;TANG Yan-qing;WANG Fei;KONG Ling-tao(Shenzhen Kangning Hospital,Shenzhen 518118,China)

机构地区：[1]深圳市康宁医院,518118 [2]中国医科大学附属第一医院

出　　处：《临床精神医学杂志》2020年第3期169-173,共5页Journal of Clinical Psychiatry

基　　金：辽宁省自然科学基金(201602833)。

摘　　要：目的:探讨女性重性抑郁障碍患者体质量指数(BMI)与脑白质完整性异常的相关性。方法:收集自2017年10月至2018年10月门诊就诊的女性重性抑郁障碍患者58例(患者组)及年龄、BMI、受教育程度相匹配的女性健康对照者57名(对照组)进行核磁共振扫描,完成临床相关量表的评定。比较两组磁共振弥散张量成像(DTI)数据,分别对两组的DTI图像与BMI进行相关性分析,并对各向异性值(FA值)进行提值计算。结果:患者组与对照组DTI比较存在两簇差异脑区,分别位于胼胝体压部及体部、右下额枕束,且患者组的FA值低于对照组。患者组BMI与右侧外囊的FA值呈正相关(r=0.531,P<0.01);对照组BMI与胼胝体体部、膝部及压部的FA值呈负相关(r=-0.497,P<0.01)。结论:女性重性抑郁障碍患者胼胝体压部、体部及右下额枕束白质完整性降低,肥胖所致的胼胝体完整性降低可能是重性抑郁障碍患者患病的相关因素。Objective:To investigate the related factors of body mass index(BMI)and abnormal white matter integrity in female patients with major depressive disorder(MDD).Method:58 female MDD patients(patient group)from October 2017 to October 2018 and 57 age,BMI and education-matched female healthy controls(control group)were scanned by magnetic resonance imaging(MRI),and were evaluated with clinical related scale.The clinical data of the two groups were analyzed.Diffusion tensor imaging(DTI)and correlation analysis between DTI images and BMI in the two groups was compared and analyzed,and the FA value of brain areas was further calculated.Results:Compared with the control group,there were two clusters of different brain regions in DTI,which were located in the splenium and body of the corpus callosum and the right lower frontal occipital tract,respectively.The FA value of the patient group is lower than that of the control group.There was a positive correlation between BMI and FA of the right external capsule in the patient group(r=0.531,P<0.01);BMI and FA of the body,genu and splenium of the corpus callosum was negatively correlated in the control group(r=-0.497,P<0.01).Conclusion:Female MDD patients have decreased white matter integrity in the splenium and body of the corpus callosum and the right inferior frontal occipital tract.The reduced integrity of the corpus callosum due to obesity may be a relevant factor in the prevalence of MDD.

关 键 词：重性抑郁障碍 体质量指数 胼胝体 右侧外囊 弥散张量成像 

分 类 号：R749.4[医药卫生—神经病学与精神病学]