多巴胺D3受体对精神分裂症患者认知功能的影响  

Effects of dopamine D3 receptors on cognitive function in patients with schizophrenia

作　　者：周琪 马可 雷蕾 于欣[1] 石川[1] ZHOU Qi;MA Ke;LEI Lei;YU Xin;SHI Chuan(Peking University Sixth Hospital,Beijing 100191,China)

机构地区：[1]北京大学第六医院,100191 [2]住友制药(苏州)有限公司

出　　处：《临床精神医学杂志》2020年第3期211-213,共3页Journal of Clinical Psychiatry

摘　　要：认知功能障碍是精神分裂症患者核心症状之一,对患者的生活质量和日常功能有重要影响。研究发现多巴胺D3受体(DRD3)主要与注意、记忆及执行功能等认知功能相关。本文从DRD3与精神分裂症认知功能的相关性及其具体机制以及相关治疗进展进行综述,为改善精神分裂症患者相关认知功能障碍提供依据。Cognitive impairment is one of the core symptoms in patients with schizophrenia.It plays an important role in the patients'daily life.A series of studies have found that dopamine D3 receptor is associated with cognitive functions,mainly including attention,memory and executive function.We expounded the correlation between dopamine D3 receptor and cognitive function of schizophrenia,accompanied by its mechanisms and the related treatment progress,for providing evidence for improvement of cognitive impairment in schizophrenic patients.

关 键 词：精神分裂症 认知功能 多巴胺D3受体 

分 类 号：R749.3[医药卫生—神经病学与精神病学]