乳腺癌根治术患者术后血清抗酒石酸盐酸性磷酸酶5b和糖类抗原15-3及白细胞介素-6水平与骨转移的关系  

Relationship between the levels of serum tartrate resistant acid phosphatase 5b,carbohydrate antigen 15-3,interleukin-6 and bone metastases in patients with breast cancer after radical mastectomy

作　　者：肖莉[1] 任峰 李冰[1] 杨梦 XIAO Li;REN Feng;LI Bing;YANG Meng(Department of Clinical Laboratory,the Central Hospital of Xinxiang City,Xinxiang 453000,Henan Province,China)

机构地区：[1]新乡市中心医院检验科,河南新乡453000

出　　处：《新乡医学院学报》2020年第5期441-443,447,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨乳腺癌根治术患者术后血清抗酒石酸盐酸性磷酸酶5b(TRACP5b)、糖类抗原15-3(CA15-3)、白细胞介素-6(IL-6)水平与骨转移的关系。方法选择2017年12月至2018年12月新乡市中心医院收治的122例行乳腺癌根治术患者为研究对象,术后1周检测患者血清TRACP5b、CA15-3、IL-6水平;随访1 a,记录患者骨转移发生情况;采用Pearson、Spearman相关性分析方法分析乳腺癌根治术后血清TRACP5b、CA15-3、IL-6水平与骨转移的相关性。结果122例患者中,无骨转移90例,骨转移32例,骨转移发生率为26.23%。骨转移患者术后血清TRACP5b、CA15-3、IL-6水平高于无骨转移患者(P<0.05),多发病灶患者术后血清TRACP5b、CA15-3、IL-6水平高于单发病灶患者(P<0.05)。乳腺癌根治术后患者血清TRACP5b、CA15-3水平与IL-6水平呈显著正相关(r=0.4126、0.4078,P<0.001)。乳腺癌根治术后患者血清TRACP5b、CA15-3、IL-6水平与骨转移程度呈显著正相关(r=0.5437、0.5328、0.3867,P<0.001)。结论乳腺癌患者术后血清TRACP5b、CA15-3、IL-6水平与骨转移的发生密切相关,且术后血清TRACP5b、CA15-3、IL-6水平越高,发生骨转移的程度越重。Objective To explore the relationship between the levels of serum tartrate resistant acid phosphatase 5b(TRACP5b),carbohydrate antigen 15-3(CA15-3),interleukin 6-(IL-6)and bone metastasis in patients with breast cancer after radical mastectomy.Methods A total of 122 patients underwent radical mastectomy in Xinxiang Central Hospital from December 2017 to December 2018 were selected as the study subjects.At one week after surgery,the levels of serum TRACP5b,CA15-3,IL-6 were detected.The patients were followed up for one year to record the occurrence of bone metastases.The correlation between serum TRACP5b,CA15-3,IL-6 levels and bone metastasis after radical mastectomy was analyzed by Pearson and Spearman correlation analysis.Results Among the 122 patients,there were 90 cases without bone metastases and 32 cases with bone metastases(26.23%).After surgery,the levels of serum TRACP5b,CA15-3 and IL-6 in patients with bone metastasis were higher than those without bone metastasis(P<0.05);and the levels of serum TRACP5b,CA15-3 and IL-6 in patients with multiple lesions were higher than those with single lesion(P<0.05).After radical mastectomy,the levels of serum TRACP5b and CA15-3 were significantly positively correlated with IL-6 level(r=0.4126,0.4078;P<0.001);the levels of serum TRACP5b,CA15-3 and IL-6 were significantly positively correlated with bone metastases(r=0.5437,0.5328,0.3867;P<0.001).Conclusion The levels of serum TRACP5b,CA15-3 and IL-6 are closely related to occurrence of bone metastases in patients with breast cancer after radical mastectomy.The higher the serum levels of TRACP5b,CA15-3 and IL-6,the greater the degree of bone metastasis.

关 键 词：骨转移 乳腺癌 抗酒石酸盐酸性磷酸酶5b 糖类抗原15-3 白细胞介素-6 

分 类 号：R739.9[医药卫生—肿瘤]