180例黏膜相关淋巴瘤患者的临床特征和预后分析  

Analysis of clinical and prognostic features in 180 patients with mucosa associated lymphoma tissue lymphoma

作　　者：曾艳 王劲 刘瑜 彭翠翠 金婕 周旭 曾东风 Yan Zeng;Jin Wang;Yu Liu;Cuicui Peng;Jie Jin;Xu Zhou;Dongfeng Zeng(Department of Hematology,Daping Hospital,Army Medical University,Chongqing 400042,China)

机构地区：[1]陆军军医大学大坪医院血液科,重庆市400042

出　　处：《中国肿瘤临床》2020年第9期433-437,共5页Chinese Journal of Clinical Oncology

摘　　要：目的:对黏膜相关淋巴组织(mucosa associated lymphoid tissue,MALT)进行较大样本的单中心回顾性分析,获取其临床特征及生存相关影响因素数据。方法:回顾性分析2012年9月至2019年5月陆军军医大学大坪医院经病理活检确诊的180例MALT淋巴瘤患者。结果:全组180例患者,其中男性99例(55.0%),女性81例(45.0%),发病年龄31~84岁,中位年龄57岁。原发部位为胃肠59例(32.8%),眼66例(36.7%),其他结外原发部位包括肺、咽淋巴环、甲状腺、腮腺和睾丸等,共55例(30.6%)。临床分期Ⅰ~Ⅱ期173例(96.1%),Ⅲ~Ⅳ期7例(3.9%)。胃肠组、眼部组和其他组5年生存率(overall survival,OS)分别为96.7%、95.5%和86.4%,差异无统计学意义(P=0.118);5年无进展生存率(progression-free survival,PFS)分别为82.4%、86.6%和86.4%,差异无统计学意义(P=0.862)。预后单因素相关分析提示,低血红蛋白水平(P=0.006)、β2-微球蛋白(β2-MG)升高(P=0.013)为影响患者OS的相关因素;β2-MG升高(P=0.004)为影响患者OS及PFS的相关因素。多因素分析表明低血红蛋白水平与生存期有关(P=0.015)。结论:MALT淋巴瘤可起源于全身不同部位,其临床过程进展缓慢,复发晚,OS较长。低血红蛋白水平、β2-MG可作为MALT淋巴瘤重要的临床预后指标。Objective:A single-center retrospective analysis was performed to obtain data on the clinical characteristics and the factors influencing the survival of patients with mucosa associated lymphoma tissue lymphoma(MALT lymphoma).Method:From September2012 to May 2019,we retrospectively analyzed 180 cases of MALT lymphoma diagnosed through pathological biopsy.Result:Among the 180 patients,99(55.0%)were male and 81(45.0%)were female.The age at onset was 31-84 years,and the median age was 57 years.There were 59(32.8%),66(96.1%),and 55(3.9%)cases involving gastrointestinal,ocular,and other extranodal primary sites,which included the lung,pharyngeal lymph ring,thyroid,parotid gland,and testis,respectively.Moreover,there were 173(94.4%)cases of clinical stageⅠ-Ⅱdisease and 7 cases(5.6%)of clinical stageⅢ-Ⅳdisease.The 5-year overall survival(OS)rates in the gastrointestinal,ocular,and other groups were 96.7%,95.5%,and 86.4%,respectively,and the difference was not statistically significant(P=0.118).The 5-year progression-free survival(PFS)rates were 82.4%,86.6%,and 86.4%in the corresponding groups,respectively,and the difference was not statistically significant(P=0.862).The single-factor correlation analysis of prognosis indicated that low hemoglobin(P=0.006)and highβ2-microglobulin(P=0.013)levels were related to OS,while an increase inβ2-microglobulin(β2-MG)(P=0.004)levels was related to OS and PFS.Survival analysis showed that a low hemoglobin level was significantly associated with OS(P=0.015).Conclusions:MALT lymphoma can originate from different parts of the body.Additionally,the patients show slow clinical progress,late recurrence,and long total survival.Low hemoglobin andβ2-MG levels can be used as important indexes for clinical prognosis.

关 键 词：非霍奇金淋巴瘤 黏膜相关淋巴瘤 临床特征 预后 

分 类 号：R733.1[医药卫生—肿瘤]