门诊消化系统疾病患者幽门螺杆菌感染状况分析  

Clinical analysis of Helicobacter pylori infection in outpatients with digestive system diseases

作　　者：董方 陈东[1] 商建峰[1] 方微[1] 滕飞[1] 张睿祺 Dong Fang;Chen Dong;Shang Jianfeng;Fang Wei;Teng Fei;Zhang Ruiqi(Department of Pathology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院病理科,北京100029

出　　处：《首都医科大学学报》2020年第3期372-375,共4页Journal of Capital Medical University

基　　金：北京市医院管理中心消化内科学科协同发展中心专项经费资助(XXX01012);首都医科大学校培育基金(PYZ2018097)。

摘　　要：目的运用TaqMan探针分子检测方法分析首都医科大学附属北京安贞医院消化系统疾病患者幽门螺杆菌(Helicobacter pylori,Hp)感染现状、分布特征及不同分子分型构成,从而为防治Hp感染以及临床用药提供理论依据。方法选取2018年4月至2019年9月行胃镜检查的患者10 839例为研究对象,行Hp分子检测,并进行分子分型和感染程度分级,同时分析不同季节、性别及年龄段Hp的检出率及分子分型构成。结果 10 839例研究对象中,Hp阳性检出率为33.76%,男性高于女性(P<0.05)。Hp的检出率夏季最高,且随着年龄的增长,呈现先增加后减少的趋势,在31~40岁年龄段,检出率达到高峰,季节、年龄段间Hp的检出率差异有统计学意义(P<0.05)。Hp的两种分子分型中男性的Ⅰ型检出率高于女性(P<0.05)。结论男性Hp的检出率高于女性;Hp的检出率与季节、年龄相关;Hp的两种分子分型中,Ⅰ型的Hp检出率较高。Objective To analyze the current situation,distribution characteristics and molecular typing composition of Helicobacter pylori(Hp)infection in patients with digestive system diseases in Beijing Anzhen Hospital,Capital Medical University using Taqman probe molecular assays,so as to provide theoretical basis for prevention and treatment of Hp infection and clinical medication.Methods 10839 patients who underwent gastroscopy from April 2018 to September 2019 were selected for Hp molecular detection,molecular typing and infection degree classification.The detection rate and molecular typing composition of Hp in different months,different quarters,different genders and different ages were analyzed.Results Among the 10839 subjects,the positive rate of Hp was 33.76%,and the positive rate of males was higher than that of females(P<0.05).The positive rate of Hp was the highest in summer.It increased at first and then decreased with the increase of age.The positive rate of Hp reached the peak in the age group of 40 years old.There were significant differences in the detection rate of Hp among different seasons and different age groups(P<0.05).In the two molecular types of Hp,the detection rate of typeⅠin males was higher than that in females(P<0.05).Conclusion The positive rate of Hp in male is higher than that in female,the detection rate of Hp is related to season and age,and the detection rate of Hp in typeⅠis higher than that in typeⅡ.

关 键 词：幽门螺杆菌 分子检测 分子分型 感染 

分 类 号：R36[医药卫生—病理学]