石家庄地区输入性及本地发病的新型冠状病毒肺炎患者临床特征对比观察  

Comparative study of imported and local clinical features of COVID-19 patients in Shijiazhuang

作　　者：赵磊[1] 薛剑[1] 王瑜玲[1] 秦浩[1] 史学晗 敦子倩 王海宾[1] 陈灿 李江英 ZHAO Lei;XUE Jian;WANG Yuling;QIN Hao;SHI Xuehan;DUN Ziqian;WANG Haibin;CHEN Can;LI Jiangying(The Fifth Hospital of Shijiazhuang,Shijiazhuang 050000,China)

机构地区：[1]石家庄市第五医院,石家庄050000

出　　处：《山东医药》2020年第15期10-13,共4页Shandong Medical Journal

基　　金：石家庄市新型冠状病毒肺炎防控应急科研攻关项目(201460513A-3)。

摘　　要：目的比较石家庄地区输入性新型冠状病毒肺炎及本地发病的新型冠状病毒肺炎的临床特点及实验室检查结果,以期为本病的早期发现、早期诊治提供参考依据。方法将2020年1月21日~2020年2月25日石家庄市第五医院收治的30例新型冠状病毒肺炎患者按照流行病学史分为输入组12例、本地组18例,对比两组年龄、性别、病史、体征、临床症状及血常规、C反应蛋白、肝功能、T淋巴细胞亚群、咽拭子核酸检测结果、新型冠状病毒特异性抗体及病灶累及部位。结果两组年龄、性别比较,P>0.05,输入组年龄多集中在30~49岁,本地组年龄分布较为均匀。本地组家庭聚集性感染比例高于输入组(P<0.05)。输入组发热、无症状患者分别为11、1例,本地组分别为6、8例,两组比较,P均<0.05。输入组CRP高于本地组(P<0.05)。输入组IgM转阳天数、IgG转阳天数均高于本地组(P均<0.05)。两组血常规,肝功能,CD3+、CD4+、CD8+T细胞数,咽拭子核酸检测转阴天数,IgM、IgG抗体持续阴性及病灶累及部位比较,P均>0.05。结论石家庄地区输入性新型冠状病毒肺炎临床症状以发热、咳嗽为主,血清炎症指标水平较高,病情相对较重;石家庄地区本地发病的新型冠状病毒肺炎以家庭聚集性发病为主要特点,年龄分布比较均匀,大部分患者临床症状轻微,部分患者为无症状感染者。Objective To compare the clinical features and laboratory results of imported coronavirus disease 2019(COVID-19)patients and local COVID-19 patients in Shijiazhuang in order to provide reference for the early detection and treatment of COVID-19.Methods According to the epidemiological history,30 patients admitted to the Fifth Hospital of Shijiazhuang from January 21,2020 to February 25,2020 were divided into the imported group(12 cases)and the local group(18 cases).The age,gender,medical history,physical signs,clinical symptoms,blood cell analysis,c-reactive protein,liver function,T-lymphocyte,detection of nucleic acid,novel coronavirus-specific antibody,and lung CT lesion involvement sites in patients with COVID-19 were compared between the two groups.Results There was no difference in the age or gender between the two groups(both P>0.05).The age of COVID-19 patients in the imported group mainly ranged from 30 to 49 years,the age of COVID-19 patients in the local group was evenly distributed.The incidence of familial aggregation was higher in the local group than in the imported group(P<0.05).The imported group had 11 patients with fever and 1 asymptomatic patient,and there were 6 and 8 cases in the local group,with statistically significant difference(P<0.05).The CRP of the imported group was higher than that of the local group(P<0.05).The number of days needed for IgM and IgG turning positive in the imported group were higher than that in the local group(P<0.05).Blood cell analysis,liver function,CD3+,CD4+,CD8+,negative days of nucleic acid detection,IgM,IgG antibody negative time,and lung lesion location were not significantly different between the two groups(all P>0.05).Conclusion The clinical symptoms of imported COVID-19 patients are mainly fever and cough,with high inflammatory index and relatively serious condition;the local patients are mainly characterized by familial clustering,the age is evenly distributed,and most patients have mild clinical symptoms,and some had asymptomatic infection.

关 键 词：新型冠状病毒肺炎 输入性新型冠状病毒肺炎 本地新型冠状病毒肺炎 临床特征 石家庄市 

分 类 号：R745.7[医药卫生—神经病学与精神病学]