肝癌肝动脉栓塞化疗术后甲胎蛋白应答与疗效及上皮间质转换关系的研究  

Study on the Relationship Between Alpha-Fetoprotein Response and Efficacy and Epithelial-Mesenchymal Transition After Hepatic Artery Embolization Chemotherapy

作　　者：张嘉麟 刘文东 刘孝高 戴光明 Zhang Jialin(Department of Oncology,Third People's Hospital of Huizhou City,Huizhou 516000)

机构地区：[1]惠州市第三人民医院肿瘤内科,广东惠州516000

出　　处：《黑龙江医药》2020年第2期268-270,共3页Heilongjiang Medicine journal

基　　金：惠州市科技计划项目(编号:2019Y212)。

摘　　要：目的:观察肝癌肝动脉栓塞化疗术后甲胎蛋白(AFP)应答与疗效及上皮间质转换关系。方法:纳入2018年1月至2019年6月在我院行肝动脉栓塞化疗术的肝癌患者60例。根据肝动脉栓塞术2周后AFP与术前相比是否下降50%分为两组:AFP应答组和AFP未应答组。观察化疗效果以及收集并检测患者肝脏组织的E-钙黏连蛋(E-cadherin)、波形蛋白(Vimentin)和上皮膜抗原(EMA)的表达强度。结果:(1)AFP应答组和AFP未应答组两组的客观缓解率分别为60.00%和36.67%,化疗效果存在统计学差异(P<0.05)。(2)AFP应答组和AFP未应答组相比,AFP应答组肝癌组织中的E-cadherin较低,而Vimentin和EMA较高,三者表达强度在两组间存在统计学差异(P<0.05)。结论:AFP未应答降低肝动脉栓塞化疗术后患者的化疗效果;且AFP未应答与E-cadherin表达升高,Vimentin和EMA表达降低有关。临床对患者进行AFP应答情况和E-cadherin、Vimentin和EMA的检测,对预测患者的预后具有重要的临床意义。Objective:To observe the relationship between alpha-fetoprotein(AFP)response and epithelial-mesenchymal transition after hepatic artery embolization chemotherapy.Methods:60 patients with liver cancer who underwent hepatic artery embolization chemotherapy from January 2018 to June 2019 were enrolled.According to whether the AFP decreased by 50%after 2 weeks of hepatic artery embolization,it was divided into two groups:AFP response group and AFP non-responder group.The effects of chemotherapy and the expression levels of E-cadherin,Vimentin and epithelial membrane antigen(EMA)were collected and detected in the liver tissue of patients.Results:(1)The objective response rates of the AFP response group and the AFP non-responder group were 60.00%and 36.67%,respectively,and the chemotherapy effect was statistically different(P<0.05).(2)Compared with the AFP non-responder group,the AFP response group had lower E-cadherin and higher Vimentin and EMA,and the expression intensity of the three groups was statistically different between the two groups(P<0.05).Conclusion:AFP has no response to reduce the chemotherapy effect of patients after hepatic artery embolization chemotherapy;and AFP unresponsive and E-cadherin expression increased,Vimentin and EMA expression decreased.Clinically,patients with AFP response and E-cadherin,Vimentin and EMA have important clinical implications for predicting patient prognosis.

关 键 词：肝动脉栓塞化疗术 甲胎蛋白应答 疗效 上皮间质转换 

分 类 号：R735.7[医药卫生—肿瘤]