术中超声造影在脑胶质瘤手术切除中的应用及患者术后短期疗效评估  

The application of intraoperative contrast-enhanced ultrasonography in the surgical resection of glioma and the short-term efficacy evaluation of patients

作　　者：胡金钰 王晓华 Hu Jinyu;Wang Xiaohua(Ultrasonic Department,Haiyang People's Hospital,Haiyang 265100,China;Neurosurgery,Haiyang People's Hospital,Haiyang 265100,China)

机构地区：[1]海阳市人民医院超声科,265100 [2]海阳市人民医院神经外科,265100

出　　处：《国际医药卫生导报》2020年第11期1581-1584,共4页International Medicine and Health Guidance News

摘　　要：目的探讨术中超声造影在脑胶质瘤手术切除中的应用及患者术后短期疗效评估效果。方法回顾性分析2017年2月至2018年2月63例术前经MRI诊断且术后经病理学确诊为脑胶质瘤的患者临床资料,患者分别行术中造影(造影组,32例)和常规超声检查(对照组,31例)。比较两组患者脑胶质瘤手术切除后的总残留率及不同级别脑胶质瘤切除残留率;两组术前、术后3个月、术后6个月分别采用KPS量表、MMSE量表评估术后的短期疗效。结果术后1个月,对照组和造影组总肿瘤残留率分别是48.39%、21.88%,差异有统计学意义(P<0.05);高级别脑胶质瘤残留率分别为22.22%、64.71%,差异有统计学意义(P<0.05)。造影组中高级别脑胶质瘤术后3、6个月KPS、MMSE评分均高于对照组,差异均有统计学意义(均P<0.05)。结论术中超声造影在脑胶质瘤手术切除中可清晰显示脑胶质瘤边界及瘤周水肿带,且对于高级别脑胶质瘤切除残留及评估其术后短期疗效方面具有重要的临床辅助价值。Objective To explore the application of intraoperative contrast-enhanced ultrasound in the resection of glioma and evaluate the short-term effect of patients.Methods The clinical data of 63 patients with glioma diagnosed by MRI before operation and confirmed by pathology after operation in our hospital from February 2017 to February 2018 were analyzed retrospectively.The patients underwent intraoperative contrastenhanced ultrasound(contrast group,n=32)and conventional ultrasound(control group,n=31).The total residual rate after resection of glioma and the residual rate after resection of different grade of gliomas were compared between the two groups.KPS and MMSE scales were used to evaluate the short-term efficacy of the two groups before operation,3 and 6 months after operation.Results One month after operation,the total residual rates of the control group and the contrast group were 48.39%and 21.88%,respectively,with statistically significant difference(P<0.05);the residual rates after resection of high grade glioma were 22.22%and 64.71%,with statistically significant difference(P<0.05).The KPS and MMSE scores of patients with high grade glioma in the contrast group were higher than those in the control group at 3 and 6 months after operation,with statistically significant differences(all P<0.05).Conclusion Intraoperative contrast-enhanced ultrasound can clearly show the boundary and peritumoral edema zone of gliomas during the surgical resection of gliomas,and it has an important clinical auxiliary value for the residual resection of high-grade gliomas and the evaluation of short-term efficacy.

关 键 词：超声造影 脑胶质瘤 短期疗效 

分 类 号：R739.41[医药卫生—肿瘤]