胃泌素释放前体、神经元特异性烯醇化酶和癌胚抗原在小细胞肺癌中的诊断价值  

The effect and value of serum pro-gastrinreleasing peptide,neuron-specific enolase and carcinoembryonic antigen in the diagnosis of small cell lung cancer

作　　者：赵宝祥[1] 李华[1] 张亚君[1] 王雪辉 尹志永[1] ZHAO Baoxiang;LI Hua;ZHANG Yajun;WANG Xuehui;YIN Zhiyong(Department of Clinical Laboratory,the Second Hospital of Qinhuangdao,Qinhuangdao 066600,Hebei,China)

机构地区：[1]秦皇岛市第二医院检验科,河北秦皇岛0666000

出　　处：《癌症进展》2020年第10期1012-1014,1022,共4页Oncology Progress

摘　　要：目的探究血清癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、胃泌素释放前体(ProGRP)检测在小细胞肺癌诊断中的效果,并对临床价值进行分析。方法选取小细胞肺癌患者100例,同时选取同期体检健康人群100例作为对照,检测两组研究对象的血清ProGRP、NSE和CEA水平以及小细胞肺癌患者的免疫组化结果,比较血清ProGRP、NSE和CEA单独及联合检测的诊断效能。结果小细胞肺癌患者的血清ProGRP、NSE和CEA水平均明显高于健康人群,差异均有统计学意义(P﹤0.01)。血清ProGRP和三项联合检测与实际检查结果一致性较好(Kappa值=0.818、0.827),三项联合检测的总符合率最高,单项检测中,血清ProGRP的总符合率最高。血清ProGRP检测与免疫组化Syn的符合率最高(符合率=94.00%,Kappa值=0.938)。广泛期小细胞肺癌患者血清ProGRP和NSE水平均明显高于局限期患者,差异均有统计学意义(P﹤0.01)。结论血清ProGRP、NSE的检测效果优于CEA检测,三项指标联合检测能提高小细胞肺癌的诊断效能。血清ProGRP在小细胞肺癌诊断中的效能与免疫组化Syn结果的检测效能一致,同时血清ProGRP、NSE的检测对临床分期具有一定诊断意义。Objective To investigate the effects of serum pro-gastrinreleasing peptide(ProGRP),neuron specific enolase(NSE)and carcinoembryonic antigen(CEA)in the diagnosis of small cell lung cancer(SCLC),and to analyze the clinical value.Method One hundred patients with SCLC,and 100 healthy subjects were included in the analysis during the same period,from whom the levels of serum ProGRP,NSE and CEA as well as the immunohistochemistry findings were compared,so as to assess the diagnostic efficiency of serum ProGRP,NSE or CEA alone or in combination.Result The levels of serum ProGRP,NSE and CEA in patients with SCLC were significantly higher than those in healthy population(P<0.01).Serum ProGRP alone and the combined detection of the three markers were in good agreement with the actual results(Kappa value=0.818,0.827),besides,the combined detection demonstrated the highest consistency rate,and serum ProGRP produced the most relevant findings among the three markers utilized alone in diagnosis.The optimal consistency rate was observed for serum ProGRP in comparison with immunohistochemical staining of Syn(consistency rate=94.00%,Kappa value=0.938).Serum levels of ProGRP and NSE in SCLC patients with extensive disease were significantly higher than that in patients with limited disease(P<0.01).Conclusion The diagnostic efficiency of serum ProGRP and NSE on SCLC is better than that of CEA,furthermore,the combined detection of the three markers may improve the diagnostic efficiency for SCLC.Serum ProGRP demonstrates consistent diagnostic efficiency with the immunohistochemistry staining of Syn,meanwhile,the detection of serum ProGRP and NSE is also clinically significant for clinical staging of SCLC.

关 键 词：小细胞肺癌 肿瘤标志物 胃泌素释放肽前体 神经元特异性烯醇化酶 癌胚抗原 

分 类 号：R734.2[医药卫生—肿瘤]