早期干预对晚期肝癌肝动脉灌注化疗患者肺部感染、睡眠质量和生活质量的效果评价  

Effect of early interventions on pulmonary infection,sleep quality and quality of life in patients with advanced liver cancer undergoing hepatic artery infusion chemotherapy

作　　者：朱艳霞[1] 王小平[1] 吕君[1] 吉慧聪 ZHU Yanxia;WANG Xiaoping;LYU Jun;JI Huicong(Department of Infectious Diseases,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,He’nan,China)

机构地区：[1]郑州大学第一附属医院感染性疾病科,郑州4500520

出　　处：《癌症进展》2020年第10期1069-1071,1075,共4页Oncology Progress

基　　金：国家自然科学基金(81902470)。

摘　　要：目的探讨早期干预对晚期肝癌化疗患者肺部感染、睡眠质量和生活质量的影响。方法依据干预方式的不同将110例晚期肝癌患者分为观察组和对照组,每组55例,对照组患者接受常规护理干预,观察组患者接受早期干预。比较两组患者肺部感染情况;干预前后,采用欧洲癌症研究与治疗组织的生活质量核心问卷(EORTC QLQ-C30)比较两组患者的生活质量;采用匹兹堡睡眠质量指数量表(PSQI)比较两组患者的睡眠质量。结果观察组患者肺部感染发生率5.45%,低于对照组患者的20.00%,差异有统计学意义(P﹤0.05)。干预前,两组患者PSQI、EORTC QLQ-C30评分比较,差异均无统计学意义(P﹥0.05)。干预后,观察组患者的PSQI评分低于本组干预前,躯体功能、心理功能和社会功能评分均高于本组干预前;且观察组患者PSQI评分低于对照组患者,躯体功能、心理功能和社会功能评分均高于对照组患者,差异均有统计学意义(P﹤0.05)。结论早期干预有助于预防晚期肝癌化疗患者继发肺部感染,改善患者睡眠质量和生活质量。Objective To explore the effect of early intervention on pulmonary infection,sleep quality and quality of life in patients with advanced liver cancer undergoing hepatic artery infusion chemotherapy.Method According to different interventions administered,110 patients with advanced liver cancer were included in the analysis as study group and control group,with 55 cases in each,patients in control group received routine care,while those in study group were managed with early intervention.The pulmonary infection was compared between the two groups,the European Organization for Research and Treatment of Cancer quality of life core questionnaire 30(EORTC QOL-C30)was used to evaluate patients’quality of life,besides,Pittsburgh sleep quality index(PSQI)was applied to assess the sleep quality of patients.Result The incidence of pulmonary infection in study group was 5.45%,which was significantly lower than that in the control group at 20.00%(P<0.05).Before intervention,the PSQI and EORTC QLQ-C30 scores in the two groups were similar(P>0.05);while after interventions,the PSQI score in study group decreased significantly,with higher scores of physical function,psychological function and social function compared to those before interventions;furthermore,study group patients had significantly lower PSQI scores than control group,while the scores of physical function,psychological function and social function were higher versus control group(P<0.05).Conclusion Early intervention helps reduce the incidence of secondary pulmonary infection in patients with advanced liver cancer undergoing chemotherapy,and also improves the sleep quality and quality of life for these patients.

关 键 词：早期干预 晚期肝癌 继发肺部感染 睡眠质量 生活质量 

分 类 号：R735.7[医药卫生—肿瘤]