HLA-DQB1基因多态性与结核病易感性关系的meta分析  

Relationship between human leukocyte antigen DQB1 gene polymorphism and tuberculosis susceptibility: a meta-analysis

作　　者：王亮 费丽萍 杨凯旋 张莹 韩松 WANG Liang;FEI Li-ping;YANG Kai-xuan;ZHANG Ying;HAN Song(Department of Epidemiology,School of Public Health,Shenyang Medical College,Shenyang,Liaoning 110034,China)

机构地区：[1]沈阳医学院公共卫生学院流行病学教研室,辽宁沈阳110034

出　　处：《实用预防医学》2020年第6期641-645,共5页Practical Preventive Medicine

基　　金：国家自然科学基金(71503175);辽宁省高校创新人才项目(LR2016012);辽宁省科技厅重点研发项目(2019JH810300052);沈阳医学院硕士研究生科研创新基金项目(Y2019050y)。

摘　　要：目的基于meta分析的方法评估HLA-DQB1等位基因与结核病发病之间的关系。方法检索PubMed、mbase、Cochrane library、中国知网、万方和维普数据库中,对所有HLA-DQB1等位基因和结核病发病风险的相关文献进行数据提取和质量评价,利用REVMAN 5.0以及Stata 13.1进行等位基因与发病风险关系的meta分析。结果共纳入18篇相关文献,涉及1 674名病例组结核病患者和1 906名对照人群,meta分析结果表明HLA-DQB1*0601、HLA-DQB1*0609与结核病发病风险相关。结论特定的HLA-DQB1等位基因可能成为预测结核病发病风险的易感标志物。Objective To evaluate the relationship between human leukocyte antigen DQB1(HLA-DQB1)allele and tuberculosis incidence based on a meta-analysis.Methods PubMed,Embase,Cochrane library,Ciki,WanFang and VIP databases were searched for literatures related to alleles of HLA-DQB1 and risk of onset of tuberculosis,and then data extraction and quality evaluation were conducted.REVMAN5.0 and Stata13.1 software packages were used for the meta-analysis of relationship between alleles of HLA-DQB1 and risk of onset of tuberculosis.Results A total of 18 related literatures were included in this study,involving 1,674 tuberculosis patients in the case group and 1,906 controls in the control group.The results of the meta-analysis revealed that HLA-DQB1*0601,HLA-DQB1*0609 were correlated with the risk of onset of tuberculosis.Conclusion Specific HLA-DQB1 allele may be a susceptibility marker to predict the risk of onset of tuberculosis.

关 键 词：结核病 HLA-DQB1 等位基因 META分析 

分 类 号：R521[医药卫生—内科学]