宫颈癌组织中Hippo-Yes相关蛋白1的表达及临床意义  

Expression and clinical significance of Hippo-Yes-associated protein1 in cervical cancer

作　　者：王文慧 邵志叶[2] 陈豪 Wen-hui Wang;Zhi-ye Shao;Hao Chen(Department of Pathology,Hangzhou Obstetrics and Gynecology Hospital,Hangzhou,Zhejiang 310000,China;Department of Pathology,Cixi Maternal and Child Health Hospital,Cixi,Zhejiang 315300,China)

机构地区：[1]杭州市妇产科医院病理科,浙江杭州310000 [2]慈溪市妇幼保健院病理科,浙江慈溪315300

出　　处：《中国现代医学杂志》2020年第12期27-32,共6页China Journal of Modern Medicine

摘　　要：目的探讨宫颈癌组织中Hippo-Yes相关蛋白1(YAP1)表达及临床意义。方法选取2013年1月—2019年6月杭州市妇产科医院和慈溪市妇幼保健院收治的100例宫颈癌患者的宫颈癌组织作为宫颈癌组,100例宫颈上皮内瘤变(CIN)患者的宫颈组织作为CIN组,100例子宫肌瘤患者的正常宫颈组织作为正常组。采用免疫组织化学染色测定组织中YAP1蛋白表达。结果CIN组YAP1蛋白阳性表达率高于正常组(P<0.05),宫颈癌组YAP1蛋白阳性表达率高于CIN组(P<0.05)。临床分期Ⅱ期宫颈癌组织中YAP1蛋白阳性表达率高于Ⅰ期(P<0.05),有淋巴结转移宫颈癌组织中YAP1蛋白阳性表达率高于无淋巴结转移(P<0.05);不同年龄、组织学类型、组织学分级、宫颈浸润深度、神经脉管是否浸润及宫旁是否浸润宫颈癌组织中YAP1蛋白阳性表达率比较,差异无统计学意义(P>0.05)。YAP1阳性表达组无病生存期(DFS)和总生存期(OS)低于YAP1阴性表达组(P<0.05)。Cox比例风险模型分析显示,YAP1表达[RR=1.202(95%CI:1.114,1.415),P=0.000]、临床分期[RR=1.412(95%CI:1.325,1.503),P=0.000]及淋巴结转移[RR=1.391(95%CI:1.258,1.471),P=0.000]为宫颈癌OS的独立影响因素。结论宫颈癌组织YAP1呈高表达,YAP1表达与宫颈癌临床分期和淋巴结转移关系密切,为宫颈癌预后的独立影响因素,高表达YAP1的宫颈癌患者预后差。Objective To investigate the expression and clinical significance of Hippo-Yes-associated protein1(YAP1)in cervical cancer tissues.Methods The cervical cancer tissues of 100 cervical cancer patients were selected as the cervical cancer group,the cervical tissues of 100 patients with cervical CIN were selected as the CIN group and the normal cervical tissues of 100 patients with uterine fibroids were selected as the normal group in Hangzhou Obstetrics and Gynecology Hospital and Cixi Maternal and Child Health Hospital from January 2013 to June 2019.The expression of YAP1 protein was determined by immunohistochemical staining.Results The positive expression rate of YAP1 protein in CIN group was higher than that in normal group(P<0.05).The positive expression rate of YAP1 protein in cervical cancer group was higher than that in CIN group(P<0.05).The positive expression rate of YAP1 protein in stage II cervical cancer tissues was higher than that in stageⅠ(P<0.05).The positive expression rate of YAP1 protein in cervical cancer tissues with lymph node metastasis was higher than that without lymph node metastasis(P<0.05).The comparison of YAP1 protein positive expression rates in different ages,histological types,histological grades,cervical invasion depth,neural vascular invasion and cervical invasion of cervical tissues were not statistically significant(P>0.05).The disease-free survival(DFS)and overall survival(OS)of the YAP1 positive expression group were lower than those of the YAP1 negative expression group(P<0.05).Analysis of the COX proportional hazard model showed:YAP1 expression[RR=1.202(95%CI:1.114,1.415)],TNM stage[RR=1.412(95%CI:1.325,1.503)]and lymph node metastasis[RR=1.391(95%CI:1.258,1.471)]were independent influencing factors for the overall survival of cervical cancer.Conclusions YAP1 is highly expressed in cervical cancer tissues.YAP1 expression is closely related to the clinical stage and lymph node metastasis of cervical cancer.It is an independent influencing factor for cervical cancer prognosi

关 键 词：宫颈肿瘤 淋巴转移 预后 

分 类 号：R737.33[医药卫生—肿瘤]