苯肌动蛋白结合蛋白在前列腺癌中的表达及意义探索  

Expression and significance of anillin actin binding protein in prostate cancer

作　　者：李华君 罗文元 温志安 张毅 黄玲[1] 邹钧 LI Huajun;LUO Wenyuan;WEN Zhian;ZHANG Yi;HUANG Ling;ZOU Jun(Department of Urology.Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China)

机构地区：[1]广州医科大学附属第三医院泌尿外科,510150

出　　处：《现代泌尿生殖肿瘤杂志》2020年第1期38-42,共5页Journal of Contemporary Urologic and Reproductive Oncology

摘　　要：目的研究苯肌动蛋白结合蛋白(ANLN)在前列腺癌中的表达情况,初步探讨其与前列腺癌临床病理及预后的关系。方法利用基因表达汇编(GEO)数据库中的基因芯片数据筛选出前列腺癌与良性前列腺组织中的差异表达基因ANLN,再以免疫组化验证前列腺组织芯片并结合免疫组化评分与前列腺癌患者的临床病理参数进行分析。结果ANLN mRNA在前列腺癌组织中高表达,并且与前列腺癌的生化复发、Gleason评分相关;免疫组化评分显示ANLN蛋白在前列腺癌组织中的表达明显高于良性前列腺组织,在高TNM分期患者中的表达高于低TNM分期患者。结论ANLN在前列腺癌组织中的表达与肿瘤的进展相关,但其促癌的具体机制仍需进一步研究。Objective To investigate the expression of anillin actin binding protein(ANLN)in prostate cancer and its relationship with clinical pathology and prognosis of prostate cancer.Methods The differentially expressed gene ANLN in prostate cancer and benign prostatic tissue were screened using gene chip data on Gene Expression Omnibus.Then the prostate tissue chip was verified by immunohistochemistry,and the clinical and pathological parameters of prostate cancer patients were analyzed by immunohistochemistry score.Results ANLN was highly expressed in prostate cancer tissues and positively correlated with biochemical recurrence and Gleason score of prostate cancer.Immunohistochemical score showed that ANLN protein was significantly higher in prostate cancer tissues than in benign prostate tissues and higher expression in patients with TNM stage than in patients with low TNM stage.Conclusions The expression of ANLN in prostate cancer tissues is related to the progress of cancer.But its mechanism of promoting cancer still needs further studying.

关 键 词：苯肌动蛋白结合蛋白 前列腺癌 诊断 预后 

分 类 号：R737.25[医药卫生—肿瘤]