影响男性阻塞性睡眠呼吸暂停综合征患者阴茎勃起功能障碍的因素  

Factors affecting penile erectile dysfunction in male patients with obstructive sleep apnea syndrome

作　　者：李国平[1] 姜娜 金晓盛[1] LI Guoping;JIANG Na;JIN Xiaosheng(Department of Respiratory Medicine,Tongde Hospital of Zhejiang Province,Hangzhou 310012,China)

机构地区：[1]浙江省立同德医院呼吸科,浙江杭州310012

出　　处：《温州医科大学学报》2020年第6期493-496,共4页Journal of Wenzhou Medical University

摘　　要：目的:探讨引起男性阻塞性睡眠呼吸暂停综合征(OSAS)患者勃起功能障碍(ED)的因素及其可能机制。方法:经多导睡眠监测仪(PSG)及同步夜间阴茎勃起(NPT)测定,90例男性OSAS患者中合并ED患者48例(ED组),无ED者42例(OSAS组)。所有研究对象于次日清晨测定血清睾酮(TT)、促泌乳素(PRL)、雌二醇(E2)、卵泡刺激素(FSH)、促黄体生成素(LH)、血清一氧化氮(NO)、一氧化氮合酶(NOS)浓度。结果:2组间BMI差异有统计学意义(P<0.05),而性激素水平差异均无统计学意义(P>0.05),但ED组患者的NO、NOS水平较OSAS组患者明显降低(P<0.05),且logistic回归分析发现,肥胖、TT和NO是影响男性OSAS勃起功能障碍的主要因素(P<0.05)。其中肥胖是危险因素,而TT、NO则是保护因素。结论:男性OSAS患者发生ED可能与肥胖、TT和NO有关,OSAS患者体内NO水平可能在维持其勃起功能中起着关键性作用。Objective:To investigate the factors that cause penile erectile dysfunction(ED)in male patients with obstructive sleep apnea syndrome(OSAS)and its possible mechanism.Methods:As measured by polysomnography(PSG)and simultaneous nocturnal penile erection(NPT),of 90 male OSAS patients 48 patients were with ED(ED group)and 42 patients without ED(OSAS group).The concentrations of serum testosterone(TT),prolactin(PRL),estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),nitric oxide(no)and nitric oxide synthetase(NOS)were measured in the next morning.Results:Compared between the two groups,there was significant difference in BMI(P<0.05),but not in sex hormone levels(P>0.05).However,the levels of NO and NOS in the ED group were significantly lower than those in the OSAS group(P<0.05),and logistic regression analysis showed that obesity,TT and NO were the main factors affecting erectile dysfunction in male OSAS(all P<0.05).Obesity was a risk factor,while TT and NO were protective factors.Conclusion:The occurrence of ED in male OSAS patients may be related to obesity,TT and NO.It was speculated that the level of NO in OSAS patients may play a key role in maintaining their erectile function.

关 键 词：睡眠呼吸暂停综合征 勃起功能障碍 肥胖 性激素 一氧化氮 

分 类 号：R[医药卫生]