中药联合动脉灌注化疗对胰腺癌的临床疗效及安全性研究  

Clinical efficacy and safety of traditional Chinese medicine combined with arterial infusion chemotherapy for pancreatic cancer

作　　者：郑炜望[1] 张宝南[1] ZHENG Weiwang;ZHANG Baonan(Department of Oncology,Wuxi Traditional Chinese Medicine Hospital in Jiangsu Province,Wuxi 214000,China)

机构地区：[1]江苏省无锡市中医医院肿瘤科,江苏无锡214000

出　　处：《中国现代医生》2020年第12期5-8,共4页China Modern Doctor

摘　　要：目的研究中药联合动脉灌注化疗治疗胰腺癌的临床疗效及安全性。方法选取2009年1月~2016年11月我院收治的60例胰腺癌患者为主要研究对象,采用随机数字表法分组,每组30例。对照组患者接受动脉灌注化疗,观察组在对照组的基础上增加中药汤剂治疗,对两组生存时间、生存率、KPS评分及不良反应进行统计分析。结果治疗后对照组患者1年生存率为47%,2年生存率为23%,3年生存率为17%,中位生存时间为12.33个月。观察组患者治疗后1年生存率为67%,2年生存率为40%,3年生存率为27%,中位生存时间为22.34个月;观察组生存期明显高于对照组患者(P<0.05)。且观察组患者KPS评分与治疗前相比有显著差异,且明显优于对照组(P<0.05)。观察组患者严重不良反应发生率16.67%,明显低于对照组的36.67%,但差异无统计学意义(P>0.05)。结论在胰腺癌的临床治疗上,采用中药联合动脉灌注化疗的治疗方案,效果更加显著,可明显改善患者的各项临床症状,更有效地控制肿瘤的进展,延长患者的生存时间,提高生活质量,减少严重不良反应的发生率,值得在临床治疗上进一步推广应用。Objective To study the clinical efficacy and safety of traditional Chinese medicine combined with arterial infusion chemotherapy in the treatment of pancreatic cancer.Methods Sixty patients with pancreatic cancer treated in our hospital from January 2009 to November 2016 were selected as the study subjects.They were divided into two groups using the random number table method,with 30 patients in each group.The control group received arterial infusion chemotherapy,while the observation group was treated with traditional Chinese medicine decoction on the basis of the control group.The survival time,survival rate,KPS score and adverse reactions were compared between the two groups.Results After treatment,the one-year survival rate was 47%,the two-year survival rate was 23%,the three-year survival rate was 17%in the control group,and the median survival time was 12.33 months.The one-year survival rate was 67%,the two-year survival rate was 40%,the three-year survival rate was 27%in the observation group,and the median survival time was 22.34 months.The survival time in the observation group was significantly higher than that in the control group(P<0.05).And the KPS score in the observation group were significantly different from those before treatment,and were significantly better than those in the control group(P<0.05).The incidence of severe adverse reactions in the observation group was 16.67%,which was significantly lower than the 36.67%in the control group,but the difference was not statistically significant(P>0.05).Conclusion In the clinical treatment of pancreatic cancer,the use of Chinese medicine combined with arterial infusion chemotherapy has a more remarkable effect,which can significantly improve the clinical symptoms,more effectively control the progress of tumors,prolong the survival time of patients,improve the quality of life,and reduce the incidence of severe adverse reactions.It is worth further promotion and application in clinical treatment.

关 键 词：中药治疗 动脉灌注化疗 胰腺癌 六君子汤 

分 类 号：R735.9[医药卫生—肿瘤]