巨细胞胶质母细胞瘤5例临床病理学分析  

Clinicopathology of 5 cases of giant cell glioblastoma

作　　者：王珏 吴景[2] 何杰[2,3] WANG Jue;WU Jing;HE Jie(School of Basic Medicine,Xinxiang Medical College,Xinxiang453000,China;Department of Pathology,Anhui Cancer Hospital,Hefei230031,China;Department of Pathology,Anhui Provincial Hospital,Hefei230001,China)

机构地区：[1]新乡医学院基础医学院,河南新乡453000 [2]安徽省肿瘤医院病理科,安徽合肥230031 [3]安徽省立医院病理科,安徽合肥230001

出　　处：《中国现代医生》2020年第12期150-153,F0003,共5页China Modern Doctor

摘　　要：目的探讨巨细胞胶质母细胞瘤(Giant cell glioblastoma,GCG)的临床病理学特征、免疫表型和鉴别诊断。方法回顾性分析安徽省肿瘤医院、安徽省立医院南区病理科2013年6月~2018年5月的住院手术病例5例GCG的临床资料、病理学形态和免疫组织化学标记结果。结果5例患者中2例男性,3例女性。年龄11~61岁,平均49岁。发生于顶叶3例,发生于颞叶1例,发生于枕部1例。肿块直径3.0~8.0 cm,平均5.8 cm。组织学特征为瘤细胞多形性,以巨怪形瘤巨细胞为主,病理性核分裂像和坏死多见,网状纤维沿血管周围分布。瘤细胞GFAP表达差异较大,弥漫表达Vimentin,Ki-67约为20%~35%。结论GCG是一种罕见的具有特殊临床病理特征、预后差的中枢神经系统肿瘤。病理组织学上需与伴有间变特征的多形性黄色瘤型星形细胞瘤、胶质肉瘤等鉴别。Objective To investigate clinicopathological characteristics,immunophenotype and differential diagnosis of giant cell glioblastoma(GCG).Methods The clinical data,pathological morphology,and immunohistochemical results of 5 cases of hospitalized patients with GCG in the Department of Pathology,Anhui Provincial Cancer Hospital and Anhui Provincial Hospital from June 2013 to May 2018 were retrospectively analyzed.Results 2 of the 5 patients were male and 3 were female.They were aged 11 to 61 years,with an average of 49 years.3 cases occurred in the parietal lobe,1 in the temporal lobe,and 1 in the occipital region.Mass diameters ranged from 3.0 cm to 8.0 cm,with an average of 5.8 cm.Histological features were tumor cell pleomorphism,which is dominated by giant monstrous tumor giant cells.Pathological mitotic figures and necrosis were common,and reticular fibers were distributed around blood vessels.The expression of glial fibrillary acidic protein(GFAP)was significantly different in tumor cells.The diffuse expression of Vimentin,and Ki-67 was about 20%to 35%.Conclusion GCG is a rare central nervous system tumor with special clinicopathological characteristics and poor prognosis.Histopathologically needs to be distinguished from pleomorphic xanthocytoma astrocytoma and gliosarcoma with anaplastic features.

关 键 词：胶质母细胞瘤 巨细胞型 临床病理学 免疫表型 

分 类 号：R739.4[医药卫生—肿瘤]