光学相干断层扫描血管造影在眼底微血管定量分析中的研究进展  

Research progress of optical coherence tomography angiography in quantitative analysis of fundus microvasculature

作　　者：姜利刚 童毓华 JIANG Ligang;TONG Yuhua(Department of Ophthalmology,Quzhou Central Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine,Quzhou324000,China)

机构地区：[1]浙江中医药大学附属衢州中心医院眼科,浙江衢州324000

出　　处：《中国现代医生》2020年第12期184-192,共9页China Modern Doctor

基　　金：浙江省自然科学基金(LGF18H120002)。

摘　　要：光学相干断层扫描血管造影通过连续探测同一位置的血管内红细胞运动,生成三维血流信息,获取高分辨率的眼底血管图像。分频幅去相关血流成像演算技术,减少了因眼球轴向运动和组织运动产生的噪点及伪影,优化了信噪比,使得对毛细血管网的检测更具有连贯性。光学相干断层扫描血管造影目前已应用于糖尿病性视网膜病变、年龄相关性黄斑变性、视网膜血管阻塞、青光眼、中心性浆液性脉络膜病变等疾病的诊疗中,具有广阔的临床应用及科研前景。本文就光学相干断层扫描血管造影在眼底微血管定量分析中的应用作综合性论述。Optical coherence tomography angiography generates three-dimensional blood flow information by continuously detecting the movement of red blood cells in the same location,and obtains high-resolution images of fundus vessels.The split-spectrum amplitude decorrelation angiography(SSADA)reduces the noise and artifacts caused by the axial movement of the eyeball and tissue movement,optimizes the signal-to-noise ratio,and makes the detection of the capillary network more consistent.Optical coherence tomography angiography has been applied to the diagnosis and treatment of diseases such as diabetic retinopathy,age-related macular degeneration,retinal vascular obstruction,glaucoma,and central serous choroidal disease.It has broad clinical application and scientific research prospects.This article makes a comprehensive discussion on the application of optical coherence tomography angiography in the quantitative analysis of fundus microvasculature.

关 键 词：光学相干断层扫描血管造影 糖尿病性视网膜病变 年龄相关性黄斑变性 视网膜血管阻塞 青光眼 中心性浆液性脉络膜病变 

分 类 号：R774.1[医药卫生—眼科]