清脑舒络汤联合脑复康治疗脑卒中恢复期患者的疗效及对炎症因子和ET-1水平的影响  

Effect of Qingnaoshuluo decoction combined with Naofukang on inflammatory factors and ET-1 in convalescent stroke patients

作　　者：凌通[1] 余伟[1] 王海红[1] LING Tong;YU Wei;WANG Haihong(Department of Brain Rehabilitation,Bo’ai Hospital of Taizhou,Taizhou 318050,China)

机构地区：[1]台州市博爱医院脑康复科,浙江台州318050

出　　处：《全科医学临床与教育》2020年第5期419-422,共4页Clinical Education of General Practice

摘　　要：目的 探讨清脑舒络汤联合脑复康治疗脑卒中恢复期患者的疗效及对炎症因子和内皮素-1(ET-1)水平的影响.方法 将120例脑卒中恢复期患者按照随机数字表分为观察组和对照组,每组60例.对照组在常规康复治疗基础上进行脑复康治疗.观察组患者在常规康复治疗基础上进行清脑舒络汤联合脑复康治疗.两组患者均治疗8周.比较两组患者的治疗效果、神经及运动功能恢复、炎性反应、一氧化氮(NO)、ET-1水平、不良反应之间的差异.结果 观察组患者(93.33%)的总有效率高于对照组(78.33%),差异有统计学意义(χ2=4.18,P<0.05);经过治疗后,观察组患者的多伦多临床评分(TCSS)、美国国立卫生研究院卒中量表(NIHSS)评分、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)、ET-1水平明显低于对照组(t分别=7.64、5.77、28.02、7.50、9.92、4.06,P均<0.05),Barthel指数、肢体运动功能Fugel-Meyer(FMA)评分、日常生活活动能力(ADL)评分、NO明显高于对照组(t分别=-3.45、-8.53、-7.24、-4.06,P均<0.05).两组患者术后发生肝功能异常和胃肠道反应的发生率比较,差异均无统计学意义(χ2分别=0.34、1.03,P均>0.05).结论 采用清脑舒络汤联合脑复康能明显改善脑卒中恢复期患者的炎症因子和ET-1水平,提升运动和神经功能,治疗效果明显.Objective To explore the effect of Qingnaoshuluo decoction combined with Naofukang on the inflammatory factors and endothelin-1(ET-1)in the convalescent stroke patients.Methods According to the random number table,120 stroke patients in recovery period were divided into observation group and control group,60 cases in each.The pa⁃tients in control group were received Naofukang treatment on the basis of conventional rehabilitation.The patients in the observation group were treated with Qingnaoshuluo decoction combined with Naofukang on the basis of conventional reha⁃bilitation.Both groups were treated for 8 weeks.The therapeutic effect,neurological and motor function recovery,inflamma⁃tory factors,nitric oxide(NO),ET-1 and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(93.33%)was higher than that of the control group(78.33%),the difference was statistically significant(χ2=4.18,P<0.05).After treatment,the TCSS,NIHSS,tumor necrosis factor alpha(TNF-α),inte⁃rleukin-6(IL-6),interleukin-8(IL-8),and ET-1 in observation group were significantly lower than those in the con⁃trol group(t=7.64,5.77,28.02,7.50,9.92,4.06,P<0.05),while the Barthel index,Fugel Meyer(FMA)score,ADL score,and NO level were significantly higher than the control group(t=-3.45,-8.53,-7.24,-4.06,P<0.05).There was no significant difference in the incidences of liver dysfunction and gastrointestinal response between the two groups(χ2=0.34,1.03,P>0.05).Conclusion Qingnaoshuluo decoction combined with Naofukang can obviously improve the levels of inflammatory factors and ET-1,improve the motor and neurological function.

关 键 词：清脑舒络汤 脑复康 脑卒中 运动功能评定 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]