吕绍光主任治疗肝郁型围绝经期非器质性失眠四种常见症状用药特点的数据挖掘研究  

Data Mining Research on Four Common Symptoms of Liver Depression Type Perimenopausal Non-Organic Insomnia Treated by Doctor Lv Shaoguang

作　　者：陈婷 李红[2] CHEN Ting;LI Hong(Pingtan Comprehensive Experimental Area Traditional Chinese Medicine Hospital,Fuzhou,Fujian 350400,China;Fujian Provincial Hospital,Fuzhou,Fujian 350001,China)

机构地区：[1]平潭综合实验区中医院,福建福州350400 [2]福建省立医院,福建福州350001

出　　处：《福建中医药》2020年第3期15-18,共4页Fujian Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局第四批全国中医(临床、基础)优秀人才研修项目(国中医药人教发〔2017〕24);福建省医学创新课题(2016-CX-8);福建省中医药科研项目计划(2017 FJZYLC103)。

摘　　要：目的探索名老中医吕绍光主任对肝郁型围绝经期非器质性失眠常见症状的用药规律。方法收集吕绍光主任治疗围绝经期非器质性失眠病例307例,其中以入睡困难为主症的患者76例,以多梦为主症的患者79例,以时睡时醒为主症的患者75例,以早醒为主症的患者77例。应用频数分析、关联分析、聚类分析的方法对四症所用药物进行数据挖掘。结果①入睡困难核心药物:茯神、黄芪、紫石英、珍珠母、浮小麦、大枣、何首乌;药对3条,如茯神→远志、茯神→珍珠母等。②多梦核心药物:郁金、香附、夜交藤、合欢皮、龙骨、牡蛎;药对14条,如香附→郁金、香附→夜交藤等。③时睡时醒核心药物:生地黄、百合、麦冬、石菖蒲、远志、栀子、淡豆豉;药对3条,如:生地黄→百合、百合→远志等。④早醒核心药物:女贞子、桑椹、旱莲草、枸杞子、黄精、菟丝子、酸枣仁、柏子仁;药对2条,如:女贞子→酸枣仁、女贞子→柏子仁。结论吕老治疗入睡困难核心治则为养心安神,兼以补血益气、调和阴阳之治法;多梦核心治则为解郁安神,兼以滋阴潜阳,养肝通络之治法;时睡时醒核心治则为润肺安神,兼以通窍滋阴、清心除烦之治法;早醒核心治则为补肾安神,兼以养肝滋阴、益气补血之治法。Objective:To explore the medication rules of the common symptoms of liver stagnation type perimenopausal non-organic insomnia by Lv Shaoguang.Methods:307 cases of non-organic insomnia in perimenopausal period treated by director Lv Shaoguang were collected,among which 76 cases were mainly sleeping difficulties,79 cases were mainly multiple dreams,75 cases were mainly waking up while sleeping,77 cases were mainly early awakening.Frequency analysis,association analysis and cluster analysis were applied to data mining for drugs used in four diseases.Results:(1)The core drugs for sleeping difficulties:poriacocos,milkvetch root,fluorite,nacre,immature wheat,Chinese date,and fleeceflower root.3 pairs of drugs,such as poriacocos→milkwort root,poriacocos→nacre,etc.(2)The core drugs for multiple dreams:turmeric root tuber,nutgrass galingale rhizome,tuber fleeceflower stem,silktree albizia bark,bone fossil of big mammals,oyster shell.14 pairs of drugs,such as nutgrass galingale rhizome→turmeric root tuber,nutgrass galingale rhizome→tuber fleeceflower stem,etc.(3)The core drugs for waking up while sleeping:unprocessed rehmannia root,lily bulb,dwarf lilyturf tuber,grassleaf sweetflag rhizome,milkwort root,cape jasmine fruit,fermented soybean.3 pairs of drugs,such as unprocessed rehmannia root→lily bulb,lily bulb→milkwort root,etc.(4)The core drugs forearly awakening:glossy privet fruit,mulberry fruit,yerbadetajo herb,barbary wolfberry fruit,solomonseal rhizome,dodder seed,spine date seed,Chinese arborvitae kernel.2 pairs of drugs,such as glossy privet fruit→spine date seed,glossy privet fruit→Chinese arborvitae kernel.Conclusion:Lv Shaoguang's core treatment for sleeping difficulties is to nourish the heart and tranquilize the mind,and to invigorate the blood and Qi,and regulate the Yin and Yang.The core treatment for multiple dreams is to relieve the depression and tranquilize the mind,and to nourish Yin and Yang,and to nourish the liver and collaterals.The core treatment for waking up while sleeping is to m

关 键 词：失眠 围绝经期 肝郁型 入睡困难 多梦 时睡时醒 早醒 吕绍光 

分 类 号：R256.63[医药卫生—中医内科学]