99m Tc-MIBI SPECT-CT显像预测鼻咽癌放化疗综合治疗疗效的临床观察  

Role of 99m Tc-MIBI SPECT-CT imaging in predicting the sensitivity of nasopharyngeal carcinoma to chemoradiotherapy

作　　者：黄金[1] 赵雅洁[1] 邓豪余[1] 熊玲静[1] 赵敏[1] 李新辉[1] HUANG Jin;ZHAO Yajie;DENG Haoyu;XIONG Lingjing;ZHAO Min;LI Xinhui(Department of Nuclear Medicine,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院核医学科,湖南长沙410008

出　　处：《肿瘤基础与临床》2020年第2期124-128,共5页journal of basic and clinical oncology

基　　金：湖南省自然科学基金青年基金资助项目(2018JJ3827)。

摘　　要：目的探讨双时相99m锝-甲氧基异丁基异腈(99mTc-MIBI)标记的单光子发射计算机断层扫描-计算机断层扫描(SPECT-CT)融合显像对预测鼻咽癌放化疗综合治疗疗效的意义,并比较平面显像与断层融合显像的差异性。方法24例局部晚期鼻咽癌患者,行早期相和晚期相SPECT-CT平面显像和断层融合显像。所有患者行1周期诱导化疗和调强放疗。分析99mTc-MIBI断层融合显像的早期相和晚期相摄取比值、清除率与放化疗综合治疗疗效的关系,并比较平面显像与断层融合显像在预测疗效方面的差异。结果断层融合显像中,高疗效组(20例)与低疗效组(4例)的早期相摄取比值、晚期相摄取比值比较差异均有统计学意义(P均<0.05);但2组清除率比较差异无统计学意义(P>0.05)。断层融合显像的早期相摄取比值、清除率均高于平面显像,差异均有统计学意义(P均<0.05);但两者晚期相摄取比值比较差异无统计学意义(P>0.05)。结论99mTc-MIBI SPECT-CT显像的早期相摄取比值、晚期相摄取比值均能预测鼻咽癌放化疗综合治疗疗效,早期相摄取比值优于晚期相摄取比值,断层融合显像优于平面显像。Objective To investigate the role of double-phase Technetium-99m 2-methoxy-isobutyl-isonitrile(99mTc-MIBI)single photon emission computed tomography-computed tomography(SPECT-CT)imaging in predicting the sensitivity of nasopharyngeal carcinoma to chemoradiotherapy,and to compare the difference between scintigraphy and fusion tomography.Methods Twenty-four patients with nasopharyngeal carcinoma were enrolled.Before therapy,the early and delayed SPECT-CT scintigraphy and fusion tomography were collected.All the patients received induction chemotherapy and intensity modulated radiotherapy.The relationships between efficacy of chemoradiotherapy and the index of early uptake ratio,late uptake ratio and washout rate of 99mTc-MIBI were evaluated,the differences of scintigraphy and fusion tomography in predicting the efficacy were also compared.Results In the fusion tomography,the early uptake ratios of the high efficacy group(20 lesions)and the low efficacy group(4 lesions),and the delayed uptake ratios of the two groups had statistically significant differences(P<0.05).However,there was not a significant difference in the washout rate of 99mTc-MIBI between the two groups(P>0.05).The early uptake ratios,washout rate of the fusion tomography were higher than those of the scintigraphy(P<0.05),but the delayed uptake ratio had no significant difference between the two methods(P>0.05).Conclusion In the 99mTc-MIBI SPECT-CT imaging,both early uptake ratio and delayed uptake ratio could predict the efficacy of chemoradiotherapy in the nasopharyngeal carcinoma,moreover early uptake ratio is superior to delayed uptake ratio,and the fusion tomography is superior to scintigraphy.

关 键 词：99m锝-甲氧基异丁基异腈 单光子发射计算机断层扫描 计算机断层扫描 鼻咽癌 放疗 化疗 

分 类 号：R739.63[医药卫生—肿瘤]