系统性红斑狼疮脑病的临床特点及导致该病发生的危险因素  

Clinical features and risk factors of systemic lupus erythematosus encephalopathy

作　　者：宋艳玲 Song yanling(department of rheumatology,Beijing 401 hospital,China nuclear industry,Beijing 102413)

机构地区：[1]中国核工业北京401医院风湿免疫科,北京102413

出　　处：《当代医药论丛》2020年第8期104-106,共3页

摘　　要：目的:总结系统性红斑狼疮脑病的临床特点,分析导致该病发生的危险因素。方法:选取2015年3月至2018年3月期间中国核工业北京401医院收治的150例系统性红斑狼疮患者为研究对象。将其中64例发生系统性红斑狼疮脑病的患者作为观察组,将其中86例未发生系统性红斑狼疮脑病的患者作为对照组。观察两组患者病情的临床特点,对比其实验室检查结果,总结导致系统性红斑狼疮脑病发生的危险因素。结果:与对照组患者相比,观察组患者肢端红斑坏死及光感性皮炎的发生率均较高,其中白细胞计数及红细胞计数下降、血清肌酐水平、血清AST水平、血清ALT水平、血清C3补体含量、血清C4补体含量、尿红细胞水平及24 h蛋白尿水平异常、抗核糖体P蛋白抗体呈阳性患者的占比均较高,P<0.05。对导致观察组患者发生系统性红斑狼疮脑病的相关影响因素进行Logistic回归分析的结果显示,血清AST的水平、血清C3补体的含量及尿红细胞的水平异常、抗核糖体P蛋白抗体呈阳性是导致该病发生的独立危险因素。结论:与未发生系统性红斑狼疮脑病患者相比,系统性红斑狼疮脑病患者更易发生光感性皮炎及肢端红斑坏死。系统性红斑狼疮患者血清AST的水平、血清C3补体的含量及尿红细胞的水平异常、抗核糖体P蛋白抗体呈阳性是导致其发生系统性红斑狼疮脑病的独立危险因素。objective:to summarize the clinical features of systemic lupus erythematosus encephalopathy and analyze the risk factors leading to the occurrence of the disease.Methods:150 patients with systemic lupus erythematosus admitted to Beijing 401 hospital of China nuclear industry from March 2015 to March 2018 were selected as the study subjects.Sixty-four patients with systemic lupus erythematoencephalopathy were included as the observation group,and 86 patients without systemic lupus erythematoencephalopathy were included as the control group.The clinical characteristics of the two groups of patients were observed,and the laboratory results were compared to summarize the risk factors leading to the occurrence of sle encephalopathy.Results:compared with the control group patients,the observation group of patients with acromegaly erythema of photosensitive dermatitis induced by necrosis and incidence were higher,the white blood cell count and the decline in red blood cell count,and serum creatinine,serum AST,serum ALT levels,serum,serum content of C4 complement C3 complement content,24 h urine red blood cell level and abnormal level of proteinuria,resistance to ribosomal P protein antibody positive patients proportion are higher,P<0.05.The results of Logistic regression analysis on the factors affecting the occurrence of sle encephalopathy in the observation group showed that the serum AST level,the content of serum C3 complement,the abnormal level of urinary red blood cells,and the positive anti-ribosomal P protein antibody were the independent risk factors for the occurrence of the disease.Conclusion:compared with patients with systemic lupus erythematosus,patients with systemic lupus erythematosus encephalopathy are more likely to develop photosensitive dermatitis and extremity erythematosis necrosis.The level of serum AST,the content of serum C3 complement,the abnormal level of urinary red blood cells,and the positive anti-ribosomal P protein antibody are the independent risk factors for the occur rence of sle ence

关 键 词：系统性红斑狼疮脑病 临床特点 危险因素 

分 类 号：R742[医药卫生—神经病学与精神病学]