高危人乳头瘤病毒感染状况及其与宫颈病变的相关性分析  

High risk human papillomavirus infection status and its correlation with cervical lesions

作　　者：蒋盈盈[1] 徐玮 陶俊贞[1] JIANG Yingying;XU Wei;TAO Junzhen(Department of Gynecology and Obstetrics,Taizhou Municipal Central Hospital,Zhejiang Taizhou 318000,China)

机构地区：[1]台州市中心医院妇产科,浙江台州318000

出　　处：《中国妇幼健康研究》2020年第5期671-675,共5页Chinese Journal of Woman and Child Health Research

摘　　要：目的分析宫颈癌筛查妇女中高危人乳头瘤病毒感染(HPV)状况及其与宫颈病变的相关性。方法选取2014年3月至2017年6月于台州市中心医院接受宫颈癌筛查的2 846例妇女为研究对象,所有患者行常规妇科检查和HPV分型检测,分析高危HPV的感染状况及其与宫颈病变的关系。结果 2 846例妇女中HPV感染率为25.44%(724/2 846),高危型HPV感染率为21.01%(598/2 846),低危型HPV感染率为4.43%(126/2 846)。高危型HPV感染率前5位依次为HPV16、18、52、58、53。高危型HPV感染中单一感染率为84.28%(504/598),双重感染率为14.72%(88/598),多重感染率为1.34%(8/598)。不同年龄组妇女HPV18感染率、HPV16感染率、其他高危HPV感染率、高危HPV总感染率比较均有显著性差异(χ^2值分别为29.295、18.639、11.440、53.294,均P<0.05),以21~30岁年龄组高危HPV感染率最高,其次为≤20岁年龄组。不同年龄组妇女高危型HPV单一感染率比较有显著性差异(χ^2=15.869,P<0.05),双重感染率比较有显著性差异(P<0.05),随着年龄的增加,单一感染率逐渐增加、双重感染率逐渐降低。而多重感染率比较无显著性差异(P>0.05)。不同宫颈病变中均以HPV16感染率最高,其次为HPV18。501例患者可疑宫颈病变行活检获得组织病理学诊断,结果显示不同宫颈病变高危型HPV感染率比较有显著性差异(P<0.01),随着宫颈病变级别的升级,高危型HPV感染率呈升高趋势。不同年龄组妇女宫颈低级别病变患病率、高级别病变患病率、宫颈癌患病率比较均有显著性差异(χ^2值分别为31.638、25.273,均P<0.05),以41~50岁年龄组患病率均最高。结论高危型HPV感染在宫颈癌及癌前病变的发生和发展中起重要作用,且与宫颈病变严重程度有关,其中以HPV16感染率最高,其次为HPV18,对高危型HPV感染者应密切随访,及时干预治疗,以预防宫颈癌的发生。Objective To explore current status of high risk human papillomavirus(HPV) infection among women who received cervical cancer screening and its correlation with cervical lesions. Methods A total of 2 846 women who received free cervical cancer screening in our hospital from March 2014 to June 2017 were enrolled. All women underwent routine gynecological examination and HPV typing. The infection status of high risk HPV and its correlation with cervical lesions were analyzed. Results Among 2 846 women,the HPV infection rate was 25.44%(724/2 846),of which,that of the high risk type was 21.01%(598/2 846) and that of the low risk type was 4.43%(126/2 846). The top 5 high risk HPV infected were HPV16,HPV18,HPV52,HPV58 and HPV53. The single infection rate of high risk HPV was 84.28%(504/598),the double infection rate of high risk HPV was 14.72%(88/598),and the multiple infection rate of high risk HPV was 1.34%(8/598). In HPV18 infection rate,HPV16 infection rate,other high risk HPV infection rate and total high risk HPV infection rate,there were significant differences among the women in different age groups(χ^2= 29.295,18.639,11.440 and 53.294 respectively,all P<0.05) with the highest high risk HPV infection rate in the 21~30 age group,followed by the ≤20 age group. There was a significant difference in the single infection rate of high risk HPV among women in different age groups(χ^2=15.869,P<0.05),and so did in the double infection rate(P<0.05). With increase in age of the women,the single infection rate of high risk HPV was gradually elevated,while the double infection rate of high risk HPV was decreased. However,there was no significant difference in multiple infection rates of high risk HPV among the different age groups(P>0.05). In the different cervical lesions,the infection rate of HPV16 was the highest,followed by HPV18. 501 women with suspicious cervical lesions were performed on biopsy to obtain histopathological diagnosis,and the results showed that there was a significant difference in the infection ra

关 键 词：宫颈癌 高危人乳头瘤病毒 宫颈病变 感染 相关性分析 

分 类 号：R737.33[医药卫生—肿瘤]