凉开三宝之紫雪“方”与“剂”的历史沿革  

Historical Evolution of"Formula"and"Preparation"of Zixue as One of Three Classic Antipyretic Preparations

作　　者：吕邵娃 武印奇 李永吉 郭玉岩 孙爽 杨大宇 杨志欣 LYU Shao-wa;WU Yin-qi;LI Yong-ji;GUO Yu-yan;SUN Shuang;YANG Da-yu;YANG Zhi-xin(Heilongjiang Key Laboratory of Pharmacodynamic Material Bases of Traditional Chinese Medicine and Natural Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学黑龙江省中药及天然药物药效物质基础研究重点实验室,哈尔滨150040

出　　处：《中国实验方剂学杂志》2020年第12期212-218,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81703724);黑龙江中医药大学科研基金项目(2018xy04)。

摘　　要：紫雪最早详细记载于《千金翼方》,后世医家又将其更名为紫雪散和紫雪丹,为凉开剂的代表方,具有较高的临床应用和研究价值。目前,紫雪的药理作用和临床应用等方面已有较多研究,但历代医书对紫雪记载略有不同,给该复方的临床合理应用及研究带来了一定的难度。加上与古方制法不同的紫雪散上市,使得研究人员对采用何种开发方式才能使经典剂型被合理继承与发扬产生了疑问。笔者通过对紫雪"方"与"剂"的历史沿革进行综述,以明确其历史脉络,为紫雪这个传统处方的现代研究与开发提供参考,也为其他经典剂型的深入挖掘提供新思路。Zixue was first recorded in detail in Qianjin Yifang,and practitioners of later generations renamed it as Zixuesan and Zixuedan,which is the representative prescription of antipyretic preparations and has high clinical application and research value.At present,there have been many studies on the pharmacological effect and clinical application of Zixue,but the medical books of the past dynasties have slightly different records on Zixue,which has brought some difficulties to the reasonable clinical application and research of this prescription.In addition to the introduction of Zixuesan,which is different from the ancient recipe,the researchers have questions about which development method can reasonably inherit and develop the classical preparation.The authors intend to summarize the historical evolution of"formula"and"preparation"of Zixue,in order to clarify its historical context,which can provide a reference for the modern research and development of this formula,and provide a new ideas for the in-depth exploration of other classic preparations.

关 键 词：紫雪 历史沿革 工艺 药物剂量 剂型 质量评价 紫雪散 

分 类 号：R22[医药卫生—中医基础理论] R28[医药卫生—中医学]