PG-Ⅰ、PG-Ⅱ、PGR联合可溶性CD44v6检测对早期胃癌的诊断价值  

The diagnostic value of PG-Ⅰ,PG-Ⅱ,PGR combined with soluble CD44v6 in early gastric cancer

作　　者：赵斌 赵欣 罗西川 侯小兵 ZHAO Bin;ZHAO Xin;LUO Xi-chuan;HOU Xiao-bing(Physical Examination Center,Beijing No.1 Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100026,China)

机构地区：[1]北京市第一中西医结合医院体检中心,北京100026

出　　处：《热带医学杂志》2020年第4期505-507,511,共4页Journal of Tropical Medicine

基　　金：北京中医药科技发展资金项目(JJ2018-13)。

摘　　要：目的探讨胃蛋白酶原-I(PG-I)、胃蛋白酶原-II(PG-II)、PG-I/PG-II(PGR)联合可溶性CD44v6检测对早期胃癌的诊断价值。方法选取北京市第一中西医结合医院2017年11月至2019年11月期间收治的胃癌患者42例,癌前病变56例。采用酶联免疫吸附法(ELISA)检测血清PG-I、PG-II、可溶性CD44v6,并计算PGR值;采用胶体金法检测患者幽门螺杆菌(HP),比较两组患者PG-I、PG-II、PGR、HP阳性率及可溶性CD44v6检测结果;并采用ROC曲线评价血清PG-I、PG-II、PGR联合可溶性CD44v6水平单独及联合诊断早期胃癌的效能。结果胃癌组PG-I(130.68±36.16)μg/L及PGR(10.94±2.06)水平均明显低于癌前病变组[(168.22±42.06)μg/L、(16.43±3.58)],PG-II水平(18.75±4.69)μg/L及HP阳性率(83.3%)明显高于癌前病变组[(14.74±3.07)μg/L、(35.7%)],差异均有统计学意义(P<0.05)。胃癌组CD44v6水平(98.35±16.18)ng/mL高于癌前病变组(68.06±12.86)ng/mL,阳性率(76.2%)也高于癌前病变组(26.8%),差异均有统计学意义(P<0.05)。ROC曲线分析显示,血清PG-I、PG-II、PGR联合可溶性CD44v6水平诊断早期胃癌的敏感度、特异度分别为94.00%、88.00%,均高于单独诊断。结论PG-I、PG-II、PGR联合可溶性CD44v6检测可有效为早期胃癌的诊断提供依据,可广泛推广。Objective To explore the diagnostic value of pepsinogen-I(PG-I),pepsinogen-II(PG-II),and PG-I/PG-II(PGR)combined with soluble CD44 v6 for early gastric cancer.Methods 42 cases of gastric cancer patients and 56 cases of precancerous lesions admitted to our hospital from November 2017 to November 2019 were selected.Serum PG-I and PG-II were detected by enzyme-linked immunosorbent assay(ELISA),and the values of PGR were calculated.Helicobacter pylori(HP)was detected by colloidal gold.The results of PG-I,PG-II,PGR,HP positive rate and soluble CD44 v6 were compared between two groups.ROC curve was used to evaluate the efficacy of serum PG-I,PG-II,PGR combined with soluble CD44 v6 in the diagnosis of early gastric cancer.Results The levels of PG-I,PG-II,and PGR in the two groups showed that the PG-I and PGR levels in the gastric cancer group were significantly lower than those in the precancerous lesion group,and the difference was statistically significant(P<0.05).However,the PG-II level in the gastric cancer group was significantly higher than that in the precancerous lesion group(P<0.05).Besides,the HP test results of the two groups showed that the HP positive rate(83.3%)was significantly higher in the gastric cancer group than that in the precancerous lesion group(35.7%)(P<0.05).Moreover,the detection results of soluble CD44 v6 level in the two groups showed that CD44 v6 level in the gastric cancer group was slightly higher than that in the precancerous lesion group,and the positive rate in the gastric cancer group was also higher than that in the precancerous lesion group,with statistically significant differences(P<0.05).ROC curve analysis showed that the sensitivity and specificity of serum PG-I,PG-II,PGR combined with soluble CD44 v6 in the diagnosis of early gastric cancer were 94.00%and 88.00%,respectively.Conclusion The detection of PG-I,PG-II,PGR combined with soluble CD44 v6 could effectively provide the basis for the diagnosis of early gastric cancer and should be widely promoted.

关 键 词：血清胃蛋白酶原 幽门螺杆菌 可溶性CD44V6 早期胃癌 

分 类 号：R735.2[医药卫生—肿瘤]