Photoacoustic viscoelasticity imaging for the detection of acute hepatitis:a feasibility study  

作　　者：Qian Wang Yujiao Shi 

机构地区：[1]MOE Key Laboratory of Laser Life Science,South China N ormal University,Guangzhou 510631,China [2]Instute of Laser Life Science,South China Normal University,Guangzhou 510631,China

出　　处：《Biophysics Reports》2020年第1期1-8,共8页生物物理学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(61627827,61331001,91539127);the Science and Technology Planning Project of Guangdong Province,China(2015B020233016,2014B020215003,2014A020215031);the Postdoctoral Innovative Talent Support Program of China(BX201700084);the Distinguished Young Teacher Project in Higher Education of Guangdong.China(YQ2015049).

摘　　要：Biomechanical assessments are essential for the understanding of physiological states and the char-acterization of certain tissue pathologies such as liver cirrhosis.In this work,we showed by the photoacoustic viscoelasticity(PAVE)imaging that obvious mechanical change was also observed in the development of the acute hepatitis owing to the hepatocyte enlargement and intracellular fluid increment,indicating that the PAVE technique can be developed as a supplementary method for detecting acute hepatitis in future.The feasibility of the PAVE imaging is validated by a group of agar phantoms.Furthermore,acute hepatitis pathological animal models were established and imaged ex vivo and in situ by the PAVE technique to demonstrate its capability for the mechanical character-ization of acute hepatitis,and the imaging results were consistent with pathological results.The fea-sibility study of detecting acute hepatitis by the PAVE technique proved that this method has potential to be developed as a clinical biomechanical imaging method to supplement current clinical strategy for liver disease detection.

关 键 词：Acute hepatitis Viscoelasticity detection Photoacoustic imaging 

分 类 号：R575.1[医药卫生—消化系统]