术前新辅助化疗对低位直肠癌手术效果的影响  

Effect of preoperative neoadjuvant chemotherapy on clinical outcome of lower rectal cancer surgery

作　　者：石好岭 杨会锋[1] 史继静 张学秀[3] SHI Haoling;YANG Huifeng;SHI Jijing;ZHANG Xuexiu(Department of General Surgery,the First People’s Hospital of Zhengzhou,Zhengzhou 450004,China;Department of Science and Education,the First People’s Hospital of Zhengzhou,Zhengzhou 450004,China;Department of Gastroenterology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州市第一人民医院普外二科,河南郑州450004 [2]郑州市第一人民医院科教科,河南郑州450004 [3]郑州大学第一附属医院消化内科,河南郑州450052

出　　处：《肿瘤基础与临床》2020年第1期60-62,共3页journal of basic and clinical oncology

基　　金：河南省高等学校重点科研项目(20A320054)。

摘　　要：目的探讨新辅助化疗对低位直肠癌手术效果的影响。方法收集2015年1月至2019年6月在郑州市第一人民医院接受治疗的68例低位直肠癌患者,根据治疗方案分为2组,开腹组34例直接行开腹手术治疗,化疗组34例开腹手术治疗前加用规范化新辅助化疗。比较观察2组患者的术前一般资料、术中情况及术后并发症等指标。结果化疗组患者的淋巴结清扫数目、远切端长度均优于开腹组(P均<0.05)。化疗组患者的术后排气时间、开始进食时间、住院时间均短于开腹组(P均<0.05)。化疗组保肛率高于开腹组,而并发症发生率低于开腹组(P均<0.05)。结论术前新辅助化疗联合常规开腹手术治疗低位直肠癌疗效显著,值得临床推广应用。Objective To explore the effect of preoperative neoadjuvant chemotherapy on operation efficacy of lower rectal cancer.Methods Sixty-eight patients with lower rectal cancer were analyzed from January 2015 to June 2019 in the First People’s Hospital of Zhengzhou,and were divided into two groups according to the treatment,the laparotomy group and the laparotomy combined with preoperative neoadjuvant chemotherapy group.The clinical data including preoperative,intraoperative and postoperative index were collected and analyzed.Results Compared with the laparotomy group,the number of dissected lymph nodes and the length of distal margin were better in the laparotomy combined with preoperative neoadjuvant chemotherapy group(P<0.05).The time of postoperative exhaust,postoperative feeding and hospitalization in the laparotomy combined with preoperative neoadjuvant chemotherapy group were shorter than those in the laparotomy group(P<0.05).The rate of sphincter preservation in the laparotomy combined with preoperative neoadjuvant chemotherapy group was higher than that in the laparotomy group(P<0.05),while the total rate of postoperative complications in the laparotomy combined with preoperative neoadjuvant chemotherapy group was lower than that in that in the laparotomy group(P<0.05).Conclusion Preoperative neoadjuvant chemotherapy combined with traditional laparotomy could increase the surgery efficacy and safety.

关 键 词：新辅助化疗 低位直肠癌 保肛 

分 类 号：R735.3+7[医药卫生—肿瘤]