以肠内营养为主的综合营养方法对溃疡性结肠炎患者肠道菌群含量与细胞因子、TLRs表达量的影响  

Effects of enteral nutrition on intestinal flora,cytokines and TLRs expression in patients with ulcerative colitis

作　　者：张海云 蔡晓波 ZHANG Hai-yun;CAI Xiao-bo(Department of Gastroenterology,Second People's Hospital of Xining.Xining 810003,China)

机构地区：[1]西宁市第二人民医院消化科,青海西宁810003

出　　处：《中国中西医结合消化杂志》2020年第5期327-330,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]探讨以肠内营养为主的综合营养方法对溃疡性结肠炎(UC)患者肠道菌群含量与细胞因子、TLRs分子表达量的影响。[方法]选取我院2018年1月~2019年1月收治的80例UC患者作为研究对象,按照随机数字法分为观察组(n=40)和对照组(n=40),其中对照组仅实施常规的对症治疗与肠外治疗,而观察组则实施以肠内营养为主的综合营养方案。分别对2组患者的肠道菌群含量与细胞因子、TLRs分子表达量进行客观比较。[结果]干预前后,观察组与对照组的乳酸杆菌、肠球菌、链球菌、双歧杆菌、类杆菌、葡萄球菌、消化球菌、酵母菌、梭杆菌和大肠杆菌等含量比较差异有统计学意义(P<0.05);观察组干预后的IL-6和TNF-α等炎性因子指标明显更低于对照组和干预前,差异有统计学意义(P<0.05),而对照组干预后的IL-10和IL-4水平则相对观察组更高(P<0.05);另外,2组间的TLR2、TLR4、TLR5和TLR9表达量差异有统计学意义(P<0.05)。[结论]以肠内营养为主的综合营养方案有助于改善UC患者肠道菌失调,减少致炎细胞因子以及助于增加TLR的含量,具备推广优势。[Objective]To investigate the effect of enteral nutrition on the expression of TLRs and intestinal flora in patients with ulcerative colitis,cytokines and TLRs expression in patients with ulcerative colitis.[Methods]Eighty cases of ulcerative colitis patients who were admitted to our hospital from January 2018 to January 2019 and were divided into observation group(n=40)and control group(n=40)according to the random number table.The control group only received conventional symptomatic treatments and parenteral treatments,while the observation group received a comprehensive nutrition program based on enteral nutrition.The contents of intestinal flora and the expressions of cytokines and TLRs were objectively compared between the two groups.[Results]Before and after the intervention,the content of lactobacillus,enterococcus,streptococcus,bifidobacteria,bacteroids,staphylococcus,digestive coccus,yeast,clostridium difficile and escherichia coli in the observation group and the control group was statistically significant(P<0.05).Inflammatory factors such as Il-6 and TNF-alpha were significantly lower in the observation group than in the control group with a statistically significant difference(P<0.05),while IL-10 and IL-4 levels in the control group were higher than observation group after intervention(P<0.05).In addition,the expression levels of TLR2,TLR4,TLR5 and TLR9 between the two groups were also statistically different(P<0.05).In addition,the expression levels of TLR2,TLR4,TLR5 and TLR9 between the two groups were also statistically significant(P<0.05).[Conclusion]The comprehensive nutrition program based on enteral nutrition is helpful to improve the intestinal bacterial imbalance in patients with ulcerative colitis,reduce inflammatory cytokines and help increase the content of TLR.

关 键 词：营养 溃疡性结肠炎 肠道菌群含量 细胞因子 

分 类 号：R574.62[医药卫生—消化系统]