睾丸间质细胞瘤12例临床病理学特征分析  

Testicular stromal cell tumor: a clinicopathological analysis of twelve cases

作　　者：张波 南平[2] 岳振营[3] 王慧[3] 李文雪[3] 孙晓辉 孙雪梅 胡营营[3] 董艳光[3] ZHANG Bo;NAN Ping;YUE Zhen-ying;WANG Hui;LI Wen-xue;SUN Xiao-hui;SUN Xue-mei;HU Ying-ying;DONG Yan-guang(Dapartment of Pathology,the Third Affiliated Hospital of Guangdong Medical University,Foshan 528000,China;Department of Gynaecology,the Central Hospital of Shengli Oilfield,Dongying257000,China;Dapartment of Pathology,the Central Hospital of Shengli Oilfield,Dongying257000,China)

机构地区：[1]广东医科大学附属第三医院病理科,广东佛山528000 [2]东营市胜利油田中心医院妇产科,山东东营257000 [3]东营市胜利油田中心医院病理科,山东东营257000

出　　处：《诊断病理学杂志》2020年第4期225-228,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨睾丸间质细胞瘤(LCT)的临床病理特征和预后。方法观察12例睾丸LCT的临床病理学和免疫组化染色,并行随访和文献复习。结果本组患者年龄5~43岁(平均28岁),首发症状大多数表现为无痛性睾丸肿物。病理特征为瘤细胞常呈大块实性团状或小梁状、小管状、假滤泡状排列,瘤细胞体积大、呈多角形,轮廓清楚,胞质丰富嗜酸性,内含多量脂质;典型的细胞核呈圆形,伴有单个明显的核仁,偶有核沟,似颗粒细胞,核分裂象稀少或缺如。少数病例可见特征性Reinke结晶体及脂褐素。肿瘤间质常不显著,内含大量薄壁血管。免疫组化vimentin、calretinin和inhibin均(+)。结论睾丸LCT发病率较低,临床易误诊,确诊需依赖病理组织学检查,尤其对儿童和年轻未育者术前行肿物穿刺活检或术中快速冷冻检查有助于手术范围的选择。Objective To investigate the clinicopathological features and prognosis of testicular leydig cell tumor (LCT).Methods The clinical pathology was observed and immunohistochemistry Max Vision staining was performed on 12 cases of testicular stromal cell tumors. Results The patients in this group were 5-43 years old (mean 28 years old),and most of the first symptoms were painless testicular masses. Histologically,tumor cells were usually arranged in large solid masses or trabecular-shaped,tubule-shaped,and pseudofollicular. Tumor cells were large,polygonal,well-defined,and had abundant eosinophilic cytoplasm. The cytoplasm was rich in lipids and the nuclei were typically round. There was a single prominent nucleolus. Occasional nuclear sulcus,granulocyte like,mitosis were rare or absent. Characteristic Reinke crystals and lipofuscin were seen in a few cases. Tumor quality was often not significant,containing a large number of thinwalled vessels. Immunohistochemistry showed that vimentin,calretinin binding protein and statins were all positively expressed. Conclusions The incidence of testicular stromal cell tumor is relatively low,which is easy to be misdiagnosed clinically,and the diagnosis needs to rely on histopathological examination,especially for children and young childless people;preoperative puncture biopsy of mass or intraoperative rapid freezing examination is helpful for the selection of surgical scope.

关 键 词：间质细胞瘤 睾丸肿瘤 免疫组化 

分 类 号：R737.2[医药卫生—肿瘤]