c-Met靶向分子影像探针的研究进展  

Research Progress of c-Met Targeted Molecular Imaging Probes

作　　者：陶吉 唐力平 顾月清 Ji Tao;Liping Tang;Yueqing Gu(School of engineering,China Pharmaceutical University,Nanjing,211198,China)

机构地区：[1]中国药科大学工学院,南京211198

出　　处：《生命科学仪器》2020年第2期23-32,22,共11页Life Science Instruments

基　　金：结肠炎癌转化相关炎症因子的筛选、监测及早期干预逆转策略的研究(国家自然科学基金91859204);结直肠癌癌前病变关键分子可视化及活体病理诊断(国家自然科学基金91859204);天然药物国家重点实验室创新研究基金(SKLNMZZCX201819)。

摘　　要：间充质上皮细胞转化因子c-Met是蛋白酪氨酸激酶受体超家族成员之一,可通过其体内唯一配体肝细胞生长因子HGF介导的HGF/c-Met信号通路参与体内许多生理过程。研究表明c-Met的过表达或异常表达与多种实体瘤的发生发展密切相关,因此,针对c-Met这个靶点开发肿瘤早期诊断与靶向治疗的药物具有重大意义。该综述简述了c-Met/HGF信号通路及其分子靶向探针在肿瘤诊断中的应用进展,可为后期c-Met造影剂的探索开发和实际应用提供思路。Mesenchymal epithelial cell transformation factor c-Met is a member of the protein tyrosine kinase receptor superfamily.It participates in many physiological processes in the body through its sole ligand,hepatocyte growth factor HGF-mediated HGF / c-Met signaling pathway.Studies have shown that its abnormal expression is closely related to the occurrence and development of various solid tumors.Therefore,it is of great significance to develop drugs for early diagnosis and targeted therapy of tumors based on c-Met.This review briefly describes the application progress of c-Met / HGF signaling pathway and its molecular targeting probes in tumor diagnosis,which can provide ideas for the later development and practical application of c-Met contrast agents.

关 键 词：C-MET蛋白 探针 分子影像 肿瘤早期诊断 

分 类 号：R730.4[医药卫生—肿瘤]