原癌基因FOS样抗原1基因多态性与胃癌易感性关系  

Association between polymorphism in protooncogene FOS like antigen 1 and the susceptibility to gastric cancer

作　　者：刘凯华[1] 付莉[2] 陈波[1] 周鑫[1] 吕游[1] 曲龙飞 黎凡 洪诗福 范春磊[1] 苏国强[1] Liu Kaihua;Fu Li;Chen Bo;Zhou Xin;Lyu You;Qu Longfei;Li Fan;Hong Shifu;Fan Chunlei;Su Guoqiang(DepartmentⅢof Gastrointestinal Surgery,the First Affiliated Hospital of Xiamen University,Xiamen 361003,China;Department of Pathology,the First Affiliated Hospital of Xiamen University,Xiamen 361003,China)

机构地区：[1]厦门大学附属第一医院胃肠外Ⅲ科,361003 [2]厦门大学附属第一医院病理科,361003

出　　处：《中华实验外科杂志》2020年第3期437-439,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨FOS样抗原1(FOSL1)基因多态性与胃癌易感性的相关性。方法收集2014年1月至2019年1月于厦门大学附属第一医院胃肠外Ⅲ科292例(观察组)新诊断胃癌患者和215例(对照组)健康体检者的资料,外周血提取DNA,采用聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)检测FOSL1不同位点的基因型,并分析FOSL1多态性与胃癌易感性的关系。组间比较采用t检验;定性资料使用χ2检验;多态位点与胃癌发生风险之间的关联采用Logistic回归分析。结果与对照组比较,观察组FOSL1 rs1892901位点基因型GG频率降低(154/215比178/292,χ2=6.240,P<0.05),AA频率增高(7/215比28/292,χ2=8.300,P<0.05),差异有统计学意义;与对照组比较,观察组rs637571位点基因型GG频率增高(119/215比187/292,χ2=3.910,P<0.05),AA频率降低(21/215比14/292,χ2=4.770,P<0.05),差异有统计学意义。rs1892901位点AA基因型患胃癌风险增加[比值比(OR)=0.32,95%可信区间(CI):0.14~0.74,P<0.05],GG基因型减少(OR=1.62,95%CI:1.11~2.36,P<0.05),差异有统计学意义;rs637571位点GG基因型患者胃癌易感性增加(OR=0.70,95%CI:0.49~1.00,P<0.05),AA基因型患者患癌风险降低(OR=2.15,95%CI:1.07~4.33,P<0.05),差异有统计学意义。调整相关因素后,rs1892901位点AA基因型仍是胃癌的易感基因(OR=0.42,95%CI:0.11~0.83,P<0.05),差异有统计学意义。结论FOSL1基因多态性与胃癌易感性明显相关。FOSL1 rs1892901位点AA基因型患胃癌风险增加。Objective Protooncogene FOS like antigen 1(FOSL1)is highly expressed in many cancers,but the relationship between polymorphism in FOSL1 and susceptibility to gastric cancer has been rarely studied.The purpose of our study was to investigate the association between FOSL1 polymorphism and the susceptibility to gastric cancer.Methods Clinical data of 292 patients with gastric cancer(observation group)diagnosed in our hospital and 215 healthy people(control group)from January 2014 to January 2019 were collected.Polymerase chain reaction(PCR)and restriction fragment length polymorphism(RFLP)were used to detect the genotypes of FOSL1,and then the relationship between FOSL1 polymorphism and susceptibility to gastric cancer was analyzed.Results Compared with the control group,the GG genotype frequency of FOSL1 rs1892901 in the observation group was lower(154/215 vs.178/292,χ2=6.240,P<0.05),and the AA genotype frequency was higher(7/215 vs.28/292,χ2=8.300,P<0.05).Compared with the control group,the GG genotype frequency of FOSL1637571 in the observation group was significantly higher(119/215 vs.187/292,χ2=3.910,P<0.05),and AA genotype frequency decreased(21/215 vs.14/292,χ2=4.770,P<0.05).At FOSL1 rs1892901 loci,AA genotype increased the risk of gastric cancer[odds ratio(OR)=0.32,95%confidence interval(CI):0.14-0.74),P<0.05],and GG genotype decreased the risk of gastric cancer(OR=1.62,95%CI:1.11-2.36,P<0.05).At FOSL1 rs637571 loci,the GG genotype increased the susceptibility of gastric cancer(OR=0.70,95%CI:0.49-1.00,P<0.05),and the AA genotype decreased the risk of gastric cancer(OR=0.70,95%CI:0.49-1.00,P<0.05).After adjusted relevant factors,AA genotype at rs1892901 loci was still a susceptible gene for gastric cancer(OR=0.42,95%CI:0.11-0.83,P<0.05).Conclusion FOSL1 polymorphism is associated with the susceptibility to gastric cancer.The AA genotype in rs1892901 had an increased risk of gastric cancer.

关 键 词：胃癌 原癌基因 FOS样抗原1 基因多态性 

分 类 号：R735.2[医药卫生—肿瘤]