DNA异常甲基化在溃疡性结肠炎中的作用研究进展  

Research progress on the role of aberrant DNA methylation in ulcerative colitis

作　　者：施飞熊 张桂虾 周宇 Shi Feixiong;Zhang Guixia;Zhou Yu(Department of Gastroenterology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学附属医院消化内科,湛江524000

出　　处：《新医学》2020年第6期409-413,共5页Journal of New Medicine

基　　金：广东省自然科学基金(2020A1515011466)。

摘　　要：溃疡性结肠炎(UC)致病机制尚未明确,可能与遗传、免疫及环境等多种因素有关。DNA甲基化在调节基因转录并在发育、分化和基因组稳定性中起重要作用。DNA异常甲基化既是肠道慢性炎症的一个结果,同时也可能在UC的发生发展中发挥作用。该文对DNA异常甲基化在UC中可能存在的机制及其临床意义等方面进行综述。The pathogenesis of ulcerative colitis(UC)remains elusive,which is probably correlated with multiple factors,such as heredity,immunity and environment,etc.DNA methylation plays an important role in regulating gene transcription,d evelopment,d ifferentiation and genomic stability.Aberrant DNA methylation is not only a consequence of chronic intestinal inflammation,b ut also may play a role in the occurrence and development of UC.In this article,the possible mechanism and clinical signifi cance of aberrant DNA methylation in UC were reviewed.

关 键 词：溃疡性结肠炎 DNA甲基化 肠道慢性炎症 

分 类 号：R574.62[医药卫生—消化系统]