肝细胞因子与非酒精性脂肪性肝病  

Hepatokines and nonalcoholic fatty liver disease

作　　者：吕枭锐 朱惠娟 龚凤英 Lyu Xiaorui;Zhu Huijuan;Gong Fengying(Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,The Translational Medicine Center of PUMCH,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫健委内分泌重点实验室,协和转化医学中心,100730

出　　处：《国际内分泌代谢杂志》2020年第3期206-210,共5页International Journal of Endocrinology and Metabolism

基　　金：北京市自然科学基金(7182130,7082079);国家自然科学基金(81370898,30771026,30540036);人社部留学人员科技活动项目择优资助经费(启动类);国家临床重点专科建设项目单位(WBYZ2011-873)。

摘　　要：非酒精性脂肪性肝病(NAFLD)是目前最常见的慢性肝病,其特点是肝脏内脂肪大量堆积(脂肪变性)。肝细胞因子指由肝脏分泌的具有自分泌、旁分泌或内分泌活性的蛋白质,主要功能为调节脂质和葡萄糖代谢。研究发现,在发生肝脏脂肪变性时,许多肝细胞因子的表达会发生变化,包括成纤维细胞生长因子21、性激素结合球蛋白、adropin、血管生成素样蛋白8、胎球蛋白A、视黄醇结合蛋白4、hepassocin、硒蛋白P和白细胞衍生趋化因子2等,它们抑制或者促进NAFLD的形成,在该过程中发挥重要作用。Nonalcoholic fatty liver disease(NAFLD),the most common chronic liver disease,is characterized by a large accumulation of fat in the liver.Hepatokines are a kind of proteins secreted by the liver which regulate lipid and glucose metabolism in autocrine,paracrine or endocrine ways.Studies showed that the expression of many hepatokines are changed when hepatic steatosis occurred,including fibroblast growth factor 21,sex hormone-binding globulin,adropin,fetuin A,retinol binding protein 4,angiopoietin-like protein 8,hepassocin and leukocyte cell-derived chemotaxin 2.These hepatokines can inhibit or promote the formation of NAFLD,and therefore play important roles in this process.

关 键 词：肝细胞因子 非酒精性脂肪性肝病 肝脂肪变性 

分 类 号：R575.5[医药卫生—消化系统]