皮肤局部用聚合物成膜递药系统的研究进展Ⅰ.成膜机制、组成、评价方法、体外释放和透皮渗透试验  

Progress of Polymeric Film-forming System for Topical Drug Delivery to the Skin Ⅰ.Film Forming Mechanism, Composition, Evaluation Method and in vitro Release and Permeation Testing

作　　者：柏佳倩 马晋隆[1] 王健[1] 倪睿[1] 黄乐乐[1] BAI Jiaqian;MA Jinlong;WANG Jian;NI Rui;HUANG Lele(National Pharmaceutical Engineering Research Center,China State Institute of Pharmaceutical Industry,Shanghai 201203)

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2020年第5期564-571,共8页Chinese Journal of Pharmaceuticals

摘　　要：皮肤疾病一直困扰着人们的生活,但传统的皮肤局部给药剂型存在保留时间短、给药频率高、患者顺应性差等局限性。聚合物成膜系统(film-forming system,FFS)是近年来开发的一种新型皮肤局部外用药物传递系统,以溶液或半固体形式直接施用于皮肤上,随溶剂挥发后可在原位形成透明的聚合物薄膜。该薄膜作为药物储库,其中的药物可持续地渗透进皮肤,发挥长效作用。聚合物FFS可减少给药频次,提高患者顺应性,在皮肤局部给药领域具有良好的发展前景。本文主要介绍了聚合物FFS的成膜机制和组成,总结了考察所形成的薄膜特性及体外释药和渗透行为的体外评价方法。Skin diseases have plagued the lives of people, but the conventional products for topical skin treatment have various limitations like short retention time, high-frequency administration and poor patient compliance. Polymeric film-forming system(FFS) is one of the novel topical delivery systems, which is applied to the skin in solutions or semisolid dosage forms, forming transparent in-situ film with the solvent evaporating. The formed film acts as a reservoir for drugs, in which drugs can continuously penetrate into skin, and exerts a long-acting effect. Moreover, polymeric FFS is beneficial to reduce the administration frequency and improve patient compliance, showing a huge potential for skin topical preparation. This review mainly introduces the film-forming mechanism and compositions of polymeric FFS, and summarizes the in vitro methods for evaluating the characteristics of the formed film and drug release and transdermal penetration behaviors.

关 键 词：聚合物 聚合物成膜系统 药物储库 长效 体外释放 透皮渗透 

分 类 号：R944.9[医药卫生—药剂学]