血小板输注对晚期肺癌患者血清中MMP-9、MMP-2及VEGF水平的影响  

Effects of platelet transfusion on the level of serum MMP-9,MMP-2 and VEGF levels in patients with advanced lung cancer

作　　者：韩丽娜[1] 孙楠[1] 王珊[1] 赵莎[2] 周欣亮[3] 赵学涛[1] HAN Li-na;SUN Nan;WANG Shan;ZHAO Sha;ZHOU Xin-liang;ZHAO Xue-tao(Department of Blood Transfusion, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;Department of Clinical Laboratory, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;Department of Chemotherapy, the Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China)

机构地区：[1]河北医科大学第四医院输血科,河北石家庄050011 [2]河北医科大学第四医院检验科,河北石家庄050011 [3]河北医科大学第四医院化疗科,河北石家庄050011

出　　处：《河北医科大学学报》2020年第6期676-679,共4页Journal of Hebei Medical University

基　　金：河北省医学科学研究重点课题(20170703)。

摘　　要：目的探讨血小板输注对晚期肺癌患者血清中金属基质蛋白酶9(metallomatrix protease9,MMP-9)、金属基质蛋白酶2(metallomatrix protease2,MMP-2)及血管内皮生长因子(vascular endothelial growth factor,VEGF)水平的影响,观察输注的血小板是否能促进晚期肺癌的转移。方法选取输注血小板的89例晚期肺癌患者,按照血小板输注是否有效[血小板增加指数(corrected count increment,CCI)>7.5为输注有效]分成血小板输注有效组和无效组,比较2组血小板输注前及血小板输注后(12~24 h)血清中MMP-9、MMP-2及VEGF水平的变化。结果研究发现血小板输注有效率为80.90%(72/89)。在血小板输注后,有效组血清中MMP-9、MMP-2及VEGF水平明显高于无效组,有效组血清中MMP-9、MMP-2及VEGF水平高于血小板输注前,差异均有统计学意义(P<0.05)。结论输注有效的血小板能使晚期肺癌患者血清MMP-9、MMP-2及VEGF的水平升高,可能对肺癌的侵袭和转移有促进作用,提示在给肺癌患者输注血小板时应该更谨慎。Objective To investigate the effects of platelet infusion on serum matrix metalloproteinase 9(MMP-9),Matrix metalloproteinase 2(MMP-2)and vascular endothelial growth factor(VEGF)levels in patients with advanced lung cancer,and to observe whether the platelets injected can promote the metastasis of advanced lung cancer.Methods A total of 89 patients with advanced lung cancer who received platelet infusion were selected.They are divided into the effective group and the ineffective group according to whether platelet infusion was effective(CCI>7.5 was effective).The serum levels of MMP-9,MMP-2 and VEGF in the two groups were compared before and after platelet infusion(12-24 h).Results The effective rate of platelet infusion was 80.90%(72/89).After platelet infusion,the serum levels of MMP-9,MMP-2 and VEGF in the effective group were significantly higher than those in the ineffective group,and the serum levels of MMP-9,MMP-2 and VEGF in the effective group were higher than those before platelet infusion,and all the differences were statistically significant(P<0.05).Conclusion The effective infusion of platelets can increase the levels of serum MMP-9,MMP-2,and VEGF in patients with advanced lung cancer,which may promote the invasion and metastasis of lung cancer,suggesting that platelets should be injected into lung cancer patients more carefully.

关 键 词：肺肿瘤 血小板输注 肿瘤浸润 

分 类 号：R734.2[医药卫生—肿瘤]