Oncometabolic surgery:Emergence and legitimacy for investigation  

作　　者：Won Jun Kim Yeongkeun Kwon Chang Min Lee Seung Hyun Lim Yong Li Junjiang Wang Weixian Hu Jiabin Zheng Gang Zhao Chunchao Zhu Wei Wang Wenjun Xiong Quan Wang Mingjie Xia Sungsoo Park 

机构地区：[1]Korea University College of Medicine,Seoul 136-701,Republic of Korea [2]Division of Foregut Surgery,Korea University College of Medicine,Seoul 136-701,Republic of Korea [3]Department of General Surgery,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China [4]Department of Gastrointestinal Surgery,Shanghai Jiao Tong University School of Medicine,Renji Hospital,Shanghai 200025,China [5]Department of Gastrointestinal Surgery,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China [6]Department of Gastrointestinal Surgery,The First Bethune Hospital of Jilin University,Changchun 130021,China

出　　处：《Chinese Journal of Cancer Research》2020年第2期252-262,共11页中国癌症研究（英文版）

摘　　要：Studies on morbid obesity have shown remarkable improvement of diabetes in patients who have undergone bariatric operations.It was subsequently shown that these operations induce diabetes remission independent of the resultant weight loss;as a result,surgeons began to investigate whether operations for gastric cancer(GC)could have the same beneficial effect on diabetes as bariatric operations.It was then shown in multiple reports that followed that certain operations for GC were able to improve or even cure type 2 diabetes mellitus(T2 DM)in GC patients.This finding gave rise to the concept of"oncometabolic surgery",in which a patient diagnosed with both GC and T2 DM undergo a single operation with the purpose of treating both diseases.With the increasing incidence of T2 DM,oncometabolic surgery has the potential to improve the quality of life and even extend survival of many GC patients.However,because the GC patient population and the bariatric patient population are wildly different and because different GC operations have different properties,the effect of oncometabolic surgery must be carefully assessed and engineered in order to maximize benefit and avoid harm.This manuscript aims to summarize the findings made so far in the field of oncometabolic surgery and to provide an outlook regarding the possibility of oncometabolic surgery being incorporated into standard clinical practice.

关 键 词：Stomach neoplasms bariatric surgery diabetes mellitus metabolic syndrome gastric bypass 

分 类 号：R735.2[医药卫生—肿瘤] R656.61[医药卫生—临床医学]