Lessons from expanded potential of embryonic stem cells:Moving toward totipotency  

作　　者：Rongrong Le Yixin Huang Anqi Zhao Shaorong Gao 

机构地区：[1]Clinical and Translational Research Center of Shanghai First Maternity&Infant Hospital,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai,200092,China

出　　处：《Journal of Genetics and Genomics》2020年第3期123-130,共8页遗传学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(31970758);National Key R&D Program of China(2016YFA0102200,2017YFA0103301,2018YFC1004001)。

摘　　要：Embryonic stem cells possess fascinating capacity of self-renewal and developmental potential,leading to significant progress in understanding the molecular basis of pluripotency,disease modeling,and reprogramming technology.Recently,2-cell-like embryonic stem cells(ESCs)and expanded potential stem cells or extended pluripotent stem cells(EPSCs)generated from early-cleavage embryos display some features of totipotent embryos.These cell lines provide valuable in vitro models to study underlying principles of totipotency,cell plasticity,and lineage segregation.In this review,we summarize the current progress in this filed and highlight the application potentials of these cells in the future.

关 键 词：2C-like ESC EPSC MERVL Zscan4 TOTIPOTENCY 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]