TOTIPOTENCY

作品数:13被引量:75H指数:3
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相关领域:生物学医药卫生更多>>
相关作者:陆文樑朱至清更多>>
相关机构:中国科学院植物研究所更多>>
相关期刊:《National Science Review》《Journal of Forestry Research》《Journal of Integrative Plant Biology》《Cell Regeneration》更多>>
相关基金:国家自然科学基金更多>>
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Spliceosomal repression:unleashing human cell totipotency
《Signal Transduction and Targeted Therapy》2024年第10期4162-4164,共3页Felipe F.Lüttmann Kee-Pyo Kim Johnny Kim 
K.-P.K.acknowledges support from the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare)(22A0203L1);J.K.acknowledges support from the German Research Council(DFG,Project 496710327);Federal Ministry for Education and Research(BMBF)with the grant number 03ZU1202FA.
In a recent publication in Cell,Li et al.reported that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptiona...
关键词:INHIBITING IMPLANTATION 
Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential被引量:2
《Cell Regeneration》2022年第1期246-266,共21页Lu Li Pishun Li Jiale Chen Li Li Yunfan Shen Yangzixuan Zhu Jiayi Liu Lu Lv Song Mao Fang Chen Guang Hu Kai Yuan 
This project has been supported by the National Natural Science Foundation of China(32170821,31771589 to K.Y);Ministry of Science and Technology of the People’s Republic of China(2021YFC2701202);Department of Science&Technology of Hunan Province(2021JJ10054,2019SK1012,2018DK2015,2017RS3013,2017XK2011 to K.Y,2019JJ40478 to P.L,and the innovative team program 2019RS1010);Central South University(2018CX032 to K.Y,and the innovation-driven team project 2020CX016)。
Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array ...
关键词:2C-like TOTIPOTENCY MERVL Rif1 PRC1.6 
Cocktails of defined chemical compounds:sufficient to induce totipotency in embryonic stem cells
《Signal Transduction and Targeted Therapy》2022年第10期3630-3631,共2页Wilfried A.Kues Dharmendra Kumar 
In a recent work published in Nature,Hu et al.1 report that a cocktail of three small chemicals is sufficient to induce totipotency in murine embryonic stem(ES)cells.Earlier this year,two other groups identified diffe...
关键词:interaction. al. INDUCE 
Towards capturing of totipotency
《Cell Research》2022年第8期705-706,共2页Cuiqing Zhong Ronghui Li Juan Carlos Izpisua Belmonte 
In June issue of Cell Research,Xu et al.demonstrate that totipotent-like stem cells(TPS cells)can be derived directly from a 2-cell mouse embryo and extended pluripotent stem(EPS)cells by a chemical cocktail(CPEC cond...
关键词:al. maintained REMODELING 
Plant cell totipotency: Insights into cellular reprogramming被引量:3
《Journal of Integrative Plant Biology》2021年第1期228-240,共13页Ying Hua Su Li Ping Tang Xiang Yu Zhao Xian Sheng Zhang 
funded by the National Natural Science Foundation of China (31730008, 31872669);the Major Program of Shandong Provincial Natural Science Foundation(2017C03)。
Plant cells have a powerful capacity in their propagation to adapt to environmental change, given that a single plant cell can give rise to a whole plant via somatic embryogenesis without the need for fertilization. T...
关键词:cell reprogramming plant cell totipotency somatic embryogenesis totipotent cell 
Decreased morphogenetic potential in peach palm stem-like cells in long-term in vitro conditions
《Journal of Forestry Research》2020年第2期485-495,共11页Erika Mendes Graner Gilvano Ebling Brondani Cristina Vieira de Almeida Katherine Derlene Batagin-Piotto Marcilio de Almeida 
Peach palm(Bactris gasipaes Kunth)has been micropropagated from pre-procambial cells that provide stem-like cell niches,(i.e.,pre-procambial cells),multipotent,pluripotent and totipotent for direct vascularization,adv...
关键词:MICROPROPAGATION MULTIPOTENCY Pluripotency TOTIPOTENCY Pre-procambial cells Peach palm Bactris gasipaes 
Lessons from expanded potential of embryonic stem cells:Moving toward totipotency被引量:2
《Journal of Genetics and Genomics》2020年第3期123-130,共8页Rongrong Le Yixin Huang Anqi Zhao Shaorong Gao 
supported by the National Natural Science Foundation of China(31970758);National Key R&D Program of China(2016YFA0102200,2017YFA0103301,2018YFC1004001)。
Embryonic stem cells possess fascinating capacity of self-renewal and developmental potential,leading to significant progress in understanding the molecular basis of pluripotency,disease modeling,and reprogramming tec...
关键词:2C-like ESC EPSC MERVL Zscan4 TOTIPOTENCY 
Moving towards totipotency without a single miR-acle
《Cell Research》2017年第5期600-601,共2页Noam Maoz Yosef Buganim 
Totipotency is the ability of a single cell to form an entire embryo, including extraembryonic tissues, an ability we have yet to recapitalize, in vitro. In a recent paper published in Science, Choi et al. showed that...
Cell totipotency:molecular features,induction,and maintenance被引量:6
《National Science Review》2015年第2期217-225,共9页Falong Lu Yi Zhang 
supported by National Institutes of Health and Howard Hughes Medical Institute.YZ is an Investigator of the Howard Hughes Medical Institute
In mammals, pluripotent stem cells can give rise to every cell type of embryonic lineage, and hold great potential in regenerative medicine and disease modeling. Guided by the mechanism underlying pluripotency, plurip...
关键词:TOTIPOTENCY PLURIPOTENCY EPIGENETICS embryonic stem cell REPROGRAMMING somatic cell nuclear transfer(SCNT) 
Role of Oct4 in the early embryo development被引量:1
《Cell Regeneration》2014年第1期50-59,共10页Guangming Wu Hans R Schöler 
This research was supported by the Max Planck Society,DFG grant SI 1695/1-2(SPP1356);NIH grant R01HD059946-01 from the Eunice Kennedy Shriver National Institute of Child Health&Human Development.We thank Areti Malapetsas for final editing。
Oct4 is a key component of the pluripotency regulatory network,and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells(ESCs)or their differentiati...
关键词:OCT4 Oct4B TOTIPOTENCY PLURIPOTENCY EMBRYO DEVELOPMENT 
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