K.-P.K.acknowledges support from the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare)(22A0203L1);J.K.acknowledges support from the German Research Council(DFG,Project 496710327);Federal Ministry for Education and Research(BMBF)with the grant number 03ZU1202FA.
In a recent publication in Cell,Li et al.reported that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptiona...
This project has been supported by the National Natural Science Foundation of China(32170821,31771589 to K.Y);Ministry of Science and Technology of the People’s Republic of China(2021YFC2701202);Department of Science&Technology of Hunan Province(2021JJ10054,2019SK1012,2018DK2015,2017RS3013,2017XK2011 to K.Y,2019JJ40478 to P.L,and the innovative team program 2019RS1010);Central South University(2018CX032 to K.Y,and the innovation-driven team project 2020CX016)。
Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array ...
In a recent work published in Nature,Hu et al.1 report that a cocktail of three small chemicals is sufficient to induce totipotency in murine embryonic stem(ES)cells.Earlier this year,two other groups identified diffe...
In June issue of Cell Research,Xu et al.demonstrate that totipotent-like stem cells(TPS cells)can be derived directly from a 2-cell mouse embryo and extended pluripotent stem(EPS)cells by a chemical cocktail(CPEC cond...
funded by the National Natural Science Foundation of China (31730008, 31872669);the Major Program of Shandong Provincial Natural Science Foundation(2017C03)。
Plant cells have a powerful capacity in their propagation to adapt to environmental change, given that a single plant cell can give rise to a whole plant via somatic embryogenesis without the need for fertilization. T...
Peach palm(Bactris gasipaes Kunth)has been micropropagated from pre-procambial cells that provide stem-like cell niches,(i.e.,pre-procambial cells),multipotent,pluripotent and totipotent for direct vascularization,adv...
supported by the National Natural Science Foundation of China(31970758);National Key R&D Program of China(2016YFA0102200,2017YFA0103301,2018YFC1004001)。
Embryonic stem cells possess fascinating capacity of self-renewal and developmental potential,leading to significant progress in understanding the molecular basis of pluripotency,disease modeling,and reprogramming tec...
Totipotency is the ability of a single cell to form an entire embryo, including extraembryonic tissues, an ability we have yet to recapitalize, in vitro. In a recent paper published in Science, Choi et al. showed that...
supported by National Institutes of Health and Howard Hughes Medical Institute.YZ is an Investigator of the Howard Hughes Medical Institute
In mammals, pluripotent stem cells can give rise to every cell type of embryonic lineage, and hold great potential in regenerative medicine and disease modeling. Guided by the mechanism underlying pluripotency, plurip...
This research was supported by the Max Planck Society,DFG grant SI 1695/1-2(SPP1356);NIH grant R01HD059946-01 from the Eunice Kennedy Shriver National Institute of Child Health&Human Development.We thank Areti Malapetsas for final editing。
Oct4 is a key component of the pluripotency regulatory network,and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells(ESCs)or their differentiati...