Spliceosomal repression:unleashing human cell totipotency  

作　　者：Felipe F.Lüttmann Kee-Pyo Kim Johnny Kim 

机构地区：[1]The Center for Cardiovascular Regeneration and Immunology at TRON-Translational Oncology at the University Medical Center of the Johannes Gutenberg-University Mainz gGmbH,Mainz,Germany [2]Department of Medical Life Sciences,College of Medicine,The Catholic University of Korea,Seoul,Republic of Korea [3]Vascular Biology and Therapeutics Program and Department of Comparative Medicine,Yale University School of Medicine,New Haven,CT,USA

出　　处：《Signal Transduction and Targeted Therapy》2024年第10期4162-4164,共3页信号转导与靶向治疗（英文）

基　　金：K.-P.K.acknowledges support from the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare)(22A0203L1);J.K.acknowledges support from the German Research Council(DFG,Project 496710327);Federal Ministry for Education and Research(BMBF)with the grant number 03ZU1202FA.

摘　　要：In a recent publication in Cell,Li et al.reported that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptional regulation in controlling developmental potential and provides a powerful model system for studying the process of human pre-implantation development in vitro.

关 键 词：INHIBITING IMPLANTATION 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]