Towards capturing of totipotency  

作　　者：Cuiqing Zhong Ronghui Li Juan Carlos Izpisua Belmonte 

机构地区：[1]Altos Labs,Inc.,San Diego,CA,USA [2]Salk Institute for Biological Studies,La Jolla,CA,USA

出　　处：《Cell Research》2022年第8期705-706,共2页细胞研究（英文版）

摘　　要：In June issue of Cell Research,Xu et al.demonstrate that totipotent-like stem cells(TPS cells)can be derived directly from a 2-cell mouse embryo and extended pluripotent stem(EPS)cells by a chemical cocktail(CPEC condition).In addition,the study shows the advanced potential of TPS cells in lineage differentiation and blastocyst-like structure generation,and provides insight into mechanistic regulation of totipotency.Totipotency,the ability of a single cell to generate all the differentiated cells in an organism,is present in the mouse zygote as well as in the 2-cell blastomeres.How to capture the totipotent state in a dish has been a challenge for many decades.Recently,studies reported the successful conversion of pluripotent stem cells(PSCs)into totipotent-like cells by spliceosomal repression1 or modulation of chromatin-remodeling enzymes.2 However,whether the totipotency can be better captured and maintained in culture directly from 2-cell embryos remains less well characterized.

关 键 词：al. maintained REMODELING 

分 类 号：Q2[生物学—细胞生物学]