A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging  

作　　者：Jiacheng Lin Qianqian Li Xiaodong Zeng Ziyang Chen Qihang Ding Yang Li Hui Zhou Xianli Meng Deliang Chen Zixin Deng Xuechuan Hong Yuling Xiao 

机构地区：[1]State Key Laboratory of Virology,Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE),School of Pharmaceutical Sciences,Wuhan University,Wuhan 430071,China [2]Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Sichuan 611137,China [3]Department of Chemistry,University of Cambridge,Cambridge CB21EW,UK [4]Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry,Chemistry and Chemical Engineering College,Gannan Normal University,Jiangxi 341000,China

出　　处：《Science China Chemistry》2020年第6期766-770,共5页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(81773674,21473041,81573383);Natural Science Foundation of Hubei Province(2017CFB711,2017CFA024,2016ACA126);the Fundamental Research Funds for the Central Universities,Tibet Autonomous Region Science and Technology Plan Project Key Project(XZ201901-GB-11);the Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology(2019020701011429);Project First-Class Disciplines Development Supported by Chengdu University of Traditional Chinese Medicine(CZYJC1903);Health Commission of Hubei Province Scientific Research Project(WJ2019M178,WJ2019M177)。

摘　　要：Osteosarcoma is the most common primary malignant tumor of bone,particularly among children and adolescents.Advances in imaging,surgical techniques,and implants have dramatically reduced the need for amputation in the past three decades.Recently,in vivo fluorescence imaging in the second near-infrared window(NIR-II,1,000–1,700 nm)shows impressive advantages of deeper tissue penetration and higher spatial resolution,which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma.To the best of our knowledge,this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model.

关 键 词：NIR-II orthotopic osteosarcoma IMAGING 

分 类 号：R738.1[医药卫生—肿瘤] O657.33[医药卫生—临床医学]