高压氧联合司来吉兰对帕金森病患者运动功能及血清miR-124、IGF-1水平的影响  

Effects of hyperbaric oxygen combined with selegiline on motor function, serum miR-124, and IGF-1 in patients with Parkinson′s disease

作　　者：陈玉民[1] 张璇[1] 冯清燕[1] 颜丙旺 魏静静 赵理英 赵文婷 伊新艳 Chen Yumin;Zhang Xuan;Feng Qingyan;Yan Bingwang;Wei Jingjing;Zhao Liying;Zhao Wenting;Yi Xinyan(Department of Neurology,Jining No.1 People′s Hospital,Jining 272000,China)

机构地区：[1]济宁市第一人民医院神经内科,山东省济宁272000 [2]济宁医学院

出　　处：《中华航海医学与高气压医学杂志》2020年第2期200-204,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探究高压氧(HBO)联合司来吉兰对帕金森病(PD)患者运动功能及血清微小RNA-124(miR-124)、胰岛素样生长因子1(IGF-1)水平的影响。方法选择2017年3月至2019年3月济宁市第一人民医院神经内科收治PD患者120例,按照随机数字表法分为对照组和观察组,每组60例。对照组患者接受左旋多巴和司来吉兰治疗,观察组在对照组治疗的基础上联合HBO治疗。治疗3个疗程后,观察2组患者的临床症状,统一PD评定量表(UPDRS)评估患者运动功能,PD非运动症状问卷量表(NMSQuest)和PD睡眠量表(PDSS)评估非运动功能;比较2组患者治疗前后血清氧化应激指标、炎性因子、IGF-1以及miR-124的水平。结果治疗30 d后,2组患者精神障碍、感觉障碍、自主神经功能障碍和睡眠障碍发生率均显著低于治疗前,且观察组治疗后均显著低于对照组治疗后(P<0.01);2组患者治疗后UPDRS II、III均显著低于治疗前,观察组治疗后UPDRS II、III评分均显著低于对照组(P<0.05或P<0.01);与治疗前比较,2组患者NMSQuest评分明显降低,PDSS评分明显升高,且观察组治疗后NMSQuest显著低于对照组,PDSS显著高于对照组(P<0.05或P<0.01);与治疗前比较,2组患者血清hs-CRP、IL-6和MDA显著降低,SOD显著升高,且观察组治疗后hs-CRP、IL-6和MDA显著低于对照组,而SOD显著高于对照组(P<0.05);2组患者miR-124相对表达量和IGF-1水平均显著高于治疗前,且观察组治疗后均显著高于对照组(P<0.05或P<0.01)。结论HBO联合司来吉兰可显著改善PD患者机体氧化应激失调,并促进miR-124和IGF-1的表达,发挥神经保护作用,并显著改善运动功能和非运动功能,提高治疗效果。Objective To investigate the effects of hyperbaric oxygen(HBO)combined with selegiline on motor function,serum microRNA-124(miR-124),insulin-like growth factor-1(IGF-1)in patients with Parkinson′s disease(PD).Methods A total of 120 PD patients,admitted in the Department of Neurology of Jining No.1 People′s Hospital from the March of 2017 to the March of 2019,were selected and divided into control group and HBO group according to the random number table method with each group consisting of 60 patients.The patients in the control group received levodopa and selegiline treatment,while the patients of HBO group were treated with HBO combined with the same medication of the control group.After three courses of treatment,clinical symptoms of the two groups were observed;motor function was assessed by the unified Parkinson′s disease rating scale(UPDRS);non-motor function was assessed by the PD non-motor symptom questionnaire(NMSQuest)and the Parkinson′s disease sleep scale(PDSS);the levels of serum oxidative stress index,inflammatory factor,IGF-1 and miR-124 before and after treatment were compared.Results After 30 d treatment,the incidences of mental disorders,sensory disturbances,autonomic nervous dysfunction and sleep disorders of the two groups were significantly lower than those before treatment,and those of HBO group after treatment were significantly lower than those of the control group(P<0.01).The UPDRS II and UPDRS III scores of both groups after treatment were significantly lower than those before treatment(P<0.05).The UPDRS II and UPDRS III scores of the HBO group after treatment were significantly lower than those of the control group(P<0.05 or P<0.01).Compared with those before treatment,the NMSQuest score of both two groups decreased and the PDSS score of both two groups increased.After treatment,the NMSQuest score of the HBO group was significantly lower than that of the control group;while the PDSS score of the HBO group was significantly higher than that of the control group(P<0.05 or P<0.01).C

关 键 词：帕金森病 高压氧 司来吉兰 微小RNA-124 胰岛素样生长因子1 

分 类 号：R742[医药卫生—神经病学与精神病学]