慢性阻塞性肺疾病基因工程动物模型研究进展  

Advances in Genetically Engineered Animal Models of Chronic Obstructive Pulmonary Disease

作　　者：刘迪[1,2] 张洪春[2] LIU Di;ZHANG Hong-chun(Beijing University of Chinese Medicine,Beijing 100029,China;Department of TCM Pulmonary Diseases,China-Japan Friendship Hospital,Center of Respiratory Medicine,China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院肺病科中日友好医院呼吸中心国家呼吸疾病临床研究中心,北京100029

出　　处：《中国生物工程杂志》2020年第4期59-68,共10页China Biotechnology

基　　金：中医药传承与创新“百千万”人才工程(岐黄工程)(2019-QTL-003)资助项目.

摘　　要：慢性阻塞性肺疾病(COPD,简称慢阻肺)是我国常见的高发病率和死亡率的慢性气道炎症性疾病,造成沉重社会经济负担。其发病与遗传及环境因素息息相关。动物模型是研究其发病机制、预防、治疗方案并鉴定潜在治疗靶点及生物标志物的重要工具。随着基因工程技术的发展和慢阻肺相关靶点及基因的不断发现,基因修饰动物模型越来越多地用于慢阻肺的研究。通过检索PubMed中已发表论文,分析了慢阻肺相关动物模型的动物种类及造模方法。然后通过文献检索及数据库挖掘等方法,分析了主要的慢阻肺易感基因及在不同物种中的区别。最后总结了慢阻肺基因工程小鼠和大鼠模型的信息和研究进展,供科研和临床人员参考使用,以便更好地开展慢阻肺的发病机制和防治方法的研究。Chronic obstructive pulmonary disease(COPD)is a common chronic airway inflammatory disease with high morbidity and mortality in China,and it has caused heavy social and economic burden.It is reported that the incidence of COPD is closely related to genetic and environmental factors.Animal model is an important tool to study its pathogenesis,prevention,treatment and identify potential therapeutic targets and biomarkers.With the development of genetic engineering technology and the continuous discovery of related targets and genes of COPD,gene modified animal models are increasingly established and used in COPD research.In this paper,we searched published papers in PubMed to analyze the animal species and modeling methods of previous models of COPD.Then we data-mined the susceptibility genes of COPD and reviewed the susceptibility genes of different species by literature and database tool analysis.Finally,we integrated and listed the information and research progress of COPD genetic engineering mouse and rat models.Those informations are convenient for researchers and clinicians to reference and use.Thereafter,they can facilitate the research of pathogenesis and prevention methods of COPD.

关 键 词：慢性阻塞性肺疾病 动物模型 基因工程 

分 类 号：Q789[生物学—分子生物学]