斑块微环境与中医阴阳学说的关系  

The Relationship between Plaque Microenvironment and the Yin-Yang Theory in Traditional Chinese Medicine

作　　者：杨颖溪 刘琪 周欢 张军平[1] YANG Yingxi;LIU Qi;ZHOU Huan;ZHANG Junping(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300112;Affiliated Hospital of Nankai University)

机构地区：[1]天津中医药大学第一附属医院,天津市300112 [2]南开大学附属医院

出　　处：《中医杂志》2020年第10期862-865,共4页Journal of Traditional Chinese Medicine

基　　金：第二批国家“万人计划”领军人才项目(津党通[2016]77号);国家自然科学基金(30973731,81473634)。

摘　　要：动脉粥样硬化斑块的形成、发展与机体和局部的内环境密切相关。斑块微环境既包括组成斑块本身的细胞成分及其分泌的因子,也包括存在于微环境中的促进斑块形成的各种病理因素。中医学认为,阴阳平衡是维持人体正常生命活动的基础,而斑块的形成是其微环境阴阳消长失衡的结果;当微环境中各种阴阳属性的因子过度转化时,则进一步加剧失衡状态,最终走向阴阳格拒,导致斑块破裂。中医药因其多靶点的调节作用,在维持机体阴阳平衡中具有显著的效果,而恢复疾病状态下的阴阳动态平衡是治疗动脉粥样硬化斑块的基本准则。The formation and development of atherosclerotic plaques are closely related to the local internal environment of the body.The plaque microenvironment includes the cellular components that make up the plaque itself and the factors secreted by them,as well as various pathological factors that exist in the microenvironment to promote plaque formation.In Chinese medicine,the balance of yin and yang is the basis for maintaining the normal life activities of the human body,and the formation of plaque is the result of the imbalance of yin and yang in its micro-environment.When the factors of various yin and yang properties in the micro-environment are over-converted,the unbalanced state is further aggravated,and finally the yin-yang rejection is caused,resulting in plaque rupture.Due to its multi-target regulation,traditional Chinese medicine has a significant effect in maintaining the balance of yin and yang in the body.Restoring the dynamic balance of yin and yang under disease state is the basic criterion for the treatment of atherosclerosis.

关 键 词：动脉粥样硬化 斑块微环境 阴阳学说 

分 类 号：R226[医药卫生—中医基础理论]